.

0 (hodnocen0 x )

BK

Praha : Academia, 1987

76 s.

000035003

1. Introduction 5 // 2. Growth stimulation and growth stimulators 9 // 2.1 Chemotactic and migration effects of growth factors 14 // 2.2 Transforming growth factors 15 // 2.3 Mechanisms of stimulation by growth factors 18 // 2.3.1 Binding of growth factors and hormones to receptors in plasma membrane 18 // 2.3.2 Transition of growth factor and hormone signals across the plasma membrane 19 // 2.3.1.1 Activating or inactivating of plasma-membrane-bound enzyme 19 // 2.3.2.2 Opening ion channels that are functionally bound to receptors 20 // 2.3.3 Growth factors and hormones and their intracellular signals 20 // 2.3.4 Internalization of growth factors and hormones 21 // 3. Oncogenes of tumor cells and their relation to the production and function of growth factors 24 // 3.1 Transforming of cells by products of oncogenes mimicking growth factors 26 // 3.2.1 Factors similar to PDGF 26 // 3.1.2 Factors similar to EGF 27 // 3.1.3 Factors similar to insulin 27 // 3.2 Transforming of cells by products of oncogenes mimicking functional activity of membrane receptors 28 // 3.3 Transforming of cells by products of oncogenes mimicking functional activity of regulatory component of intracellular messenger systems 30 // 4. Growth inhibition and growth inhibitors 33 // 4.1 Growth inhibitors 33 // 4.2 Characteristics of growth inhibitors 34 // 4.2.1 Cell, tissue and species specificity 35 // 4.2.2 Selectivity and cytotoxicity 36 // 4.2.3 Cell cycle specificity 37 // 4.3 Growth inhibition assays and inhibition efficiency 41 // 4.4 The duration of inhibition and chemical characteristics of inhibitors 43 // 4.5 Mechanisms of inhibitoin by specific inhibitors 45 // 4.6 Interaction of growth inhibitors with growth factors and hormones 46 // 4.7 Inhibitors isolated from tissues and from conditioned media 47 // 4.8 Tumor inhibiting factors 48 // 5. Tumor growth as a result of changes in growth factors and grow inhibitors action 51

(OCoLC)19322423

cnb000037367