.

0 (hodnocen0 x )

BK

4th ed.

Hoboken : John Wiley & Sons, c2011

xxv, 1428, 53 s. : il. ; 29 cm

ISBN 978-0-470-57095-1 (váz.)

Obsahuje bibliografii a rejstřík

000248954

CONTENTS // Guide to Media Resources xvi PART I // INTRODUCTION AND BACKGROUND i // Charter 1 Life ? // 1. Prokaryotes 3 // 2. Eukaryotes 6 // 3. Biochemistry: A Prologue 1 4 // 4. Genetica: A Review 1 9 // 5. The Origin of Life 28 // 6. The Biochemical Literature 34 // Chapter 2 Aqueous Solutions 4o // 1. Properties of Water 40 // 2. Acids, Bases, and Buffers 45 // Chapter 3 Thermodynamic Principles: // A Review 58 // 1. First Law of Thermodynamics: Energy Is // Conserved 52 // 2. Second Law of Thermodynamics: The Universe Tends Toward Maximum Disorder 54 // 3. Free Energy: The indicator of Spontaneity 57 // 4. Chemical Equilibria 58 // APPENPiX: Concentration Dependence of Free Energy 81 // PART H // BIOMOLECULES 65 // Chapter 4 Amin© Acids e? // 1. The Amino Acids of Proteins 67 // 2. Opticel Activity 78 // 3. “Nonstandard" Amino Acids 78 // Chapter 5 Nucleic Acids, Gene Expression, and Reeembinant BNA Technology 8? // 1. Nucleotides and Nucleic Acids 82 // 2. DNA Is the Carrier of Genetic Information 85 // 3. Double Heiical PNA 88 // 4. Gene Expression and Replication: // An Overview 95 // 5. Molecular Cloning 104 // Chapter © Techniques of Protein and Nueleie Acid Purifications ? // 1. Protein Isolation 129 // 2. Solubilities of Proteins 133 // 3. Chromatographic Separations 135 // 4. Electrophoresis 1 46 // 5. Ultracentrifugation 1 52 // 6. Nucleic Acid Fractionation 1 56 // Chapter 7 Covalent Structures of Proteins and Nucleic Acids i63 // 1. Primary Structure Determination

of Proteins 164 // 2. Nucleic Acid Sequencing 176 // 3. Chemical Evolution 1 85 // 4. Bioinformatics: An Introduction 194 // 5» Chemical Synthesis of Polypeptides 205 6. Chemical Synthesis of Oligonucleotides 209 // Chapter 8 Three-Dimensional Structures of Proteins 221 // 1. Secondary Structure 221 // 2. Fibrous Proteins 232 // 3. Globular Proteins 241 // 4. Protein Stability 259 // 5. Quaternary Structure 266 APPENDIX: Viewing Stereo Pictures 271 // Chapter 9 Protein Folding, Dynamics, and Structural Evolution 278 // 1. Protein Folding: Theory and Experiment 278 // 2. Folding Accessory Proteins 290 // 3. Protein Structure Prediction and Design 302 // 4. Protein Dynamics 306 // 5. Conformational Diseases: Amyloids and Prions 309 // 6. Structural Evolution 316 // Chapter 10 Hemoglobin; Protein Function in Microcosm ??? // 1. Hemoglobin and Myoglobin Function 323 // 2. Structure and Mechanism 331 // 3. Abnormal Hemoglobins 341 // 4. Allosteric Regulation 347 APPENDIX: Derivation of Symmetry Model Equations 354 // Chapter 11 Sugars and Polysaccharides 359 // 1. Monosaccharides 359 // 2. Polysaccharides 365 // 3. Glycoproteins 373 // Chapter 1 2 Lipids and Membranes see // 1. Lipid Classification 386 // 2. Properties of Lipid Aggregates 393 // xiii // xiv Contents // 3. Biological Membranes 399 // 4. Membrane Assembly and Protein Targeting 418 // 5. Lipoproteins 449 // PART III // MECHANISMS OF ENZYME ACTION 467 // Chapter 1 3 introduction to Enzymes 469 // 1. Historical Perspective

469 // 2. Substrate Specificity 470 // 3. Goenzymes 473 // 4. Regulation of Enzymatic Activity 474 // 5. A Primer of Enzyme Nomenclature 479 // Chapter 1 4 Rates of Enzymatic Reactione 482 // 1* Ohemical Kinetics 482 // 2. In ymc Kinetics 487 // 3. Inhibition 492 // 4. iffccts Of pH 496 // 5. Bisubstrste Reactions 497 APFINDIX: Derivations of Michaelis-Menten // igustion Variants 601 // Chapter 1 5 Enzymatic Catalysis soe // 1. Ostaly tic Mechanisms 606 // 2. Lysozyme 617 // 3. Serine Preteases 525 // 4. Brug Design 669 // PART IV // METABOLISM §67 // Chapter 16 Introduction to Motaboliem 559 // 1. Metabolic Pathways 559 // 2. Organic Reaction Mechanisms 562 // 3. Experimenta! Approaches to the Study of Metabolism 669 // 4. Thermobynamics of Phosphate Compounds 578 // 5. Oxidation-RecjMCtion Reactions 583 // 6. Thermodynamics of Life 586 // Chapter 1 7 Glycolysis 593 // 1. The Glycolytic Pathway 593 // 2. The Reactions of Glycolysis 595 // 3. Fermentation: The Anaerobic Fate of Pyruvate 614 // 4. Metabolic Regulation and Contro! 619 // 5. Metabolism of Hexoses Other than Glucose 630 // Chapter 1 8 Glycogen Metabolism ess // 1. Glycogen Breakdown 638 // 2. Glycogen Synthesis 644 // 3. Control of Glycogen Metabolism 647 // 4. Glycogen Storage Diseases 666 // Chapter 1 9 Signal Transduction 67i // 1. Hormones 671 // 2. Heterotrim eric G Proteins 688 // 3. Tyrosine Kinase-Based Signaling 699 // 4. The Phosphoinositide Cascade 725 // Chapter 20 Transport through Membranes 744 // 1.

Thermodynamics of Transport 744 // 2. Kinetics and Mechanisms of Transport 745 // 3. ATP-Driven Active Transport 758 // 4. Ion Gradient-Driven Active Transport 768 // 5. Neurotransmission 771 // Chapter 21 Citric Acid Cycle 789 // 1. Cycle Overview 789 // 2. Metabolic Sources of Acetyl-Coenzyme A 792 // 3. Enzymes of the Citric Acid Cycle 806 // 4. Regulation of the Citric Acid Cycle 815 // 5. The Amphibolic Nature of the Citric Acid Cycle 817 // Chapter 22 Electron Transport and Oxidative Phosphorylation 823 // 1 » The Mitochondrion 823 // 2. Electron Transport 828 // 3. Oxidative Phosphorylation 845 // 4. Control of ATP Production 862 // Chapter 23 Other Pathways of Carbohydrate Metabolism 8?i // 1. Gluconeogenesjs 871 // 2. The Glyoxylate Cycle 880 // 3. Biosynthesis of Oligosaccharides and Glycoproteins 880 // 4» The Pentose Phosphate Pathway 892 // Chapter 24 Photosynthesis 901 // 1, Chloroplasts 901 // 2, Light Reactions 903 // 3, Dark Reactions 926 // Chapter 25 Lipid Metabolism 940 // 1. Lipid Digestion, Absorption, and Transport 940 // 2. Fatty Acid Oxidation 945 // 3. Ketone Bodies 959 // 4. Fatty Acid Biosynthesis 961 // Contents XV // 5. Regulation of Fatty Acid Metabolism 973 // 6. Cholesterol Metabolism 975 // 7. Eicosanoid Metabolism: Prostaglandins, Prostacyclins, Thromboxanes, Leukotrienes, and Lipoxins 993 // 8. Phospholipid and Glycolipid Metabolism 1 004 // Chapter 26 Amino Acid Metabolism 1019 // 1. Amino Acid Deamination 1019 // 2. The Urea Cycle 1 025

// 3. Metabolic Breakdown of Individual Amino Acids 1 029 // 4. Amino Acids as Biosynthetic Precursors 1 047 // 5. Amino Acid Biosynthesis 1 064 // 6. Nitrogen Fixation 1078 // Chapter 27 Energy Metabolism: Integration and Organ Specialisation iosa // 1. Mßjor Pathways and Strategies of Energy Metabolism: A Summary 1088 // 2. Organ Specialization 1 090 // 3. Metaboljp Homeostasis: Regulation of Appetite, Energy Expenditure, and Body Weight 1 095 // 4. Metabolic Adaptation 1101 // Chapter 28 Nueleotide Metabolism no? // 1. Synthesis of Purine Ribonucleotides 1107 // 2. Synthesis of Pyrimidine Ribonucleotides 1114 // 3. Formation Of Peoxyribonucleotides 1119 // 4. Nucleotide Pegradation 1130 // 5. Biosynthesis of Nucleotide Coenzymes 1136 // PART V // EXPRESSION AND TRANSMISSION OF GENETIC INFORMATION 1143 // Charter 29 Nueleie Acid Structures ins // 1. Pouble Helical Structures 1145 // 2. Forces Stabilizing Nucleic Acid Structures 1151 // 3. Sppercoiled DNA 1158 // Chapter 30 DNA Replication, Repair, and Recombination 1173 // 1. DNA Replication: An Overview 1173 // 2. Enzymes of Replication 1176 // 3. Prokaryotic Replication 1 1 90 // 4. Eukaryotic Replication 1 201 // 5. Repair of DNA 1213 // 6. Recombination and Mobile Genetic Elements 1225 // 7. DNA Methylation and Trinucleotide Repeat Expansions 1 246 // Chapter 31 Transcription 1260 // 1. The Role of RNA in Protein Synthesis 1 260 // 2. RNA Polymerase 1 265 // 3. Control of Transcription in Prokaryotes 1 283 // 4. Post-Transcriptional

Processing 1301 // Chapter 32 Translation 1338 // 1. The Genetic Code 1 338 // 2. Transfer RNA and Its Aminoacylation 1 345 // 3. Ribosomes 1 362 // 4. Control of Eukaryotic Translation 1 398 // 5. Post-Translational Modification 1 403 // 6. Protein Degradation 1 408 // ‘Chapter 33 Viruses: Paradigms for Cellular Function w-i // 1. Tobacco Mosaic Virus W-3 // 2. Icosahedral Viruses W-8 // 3. Bacteriophage X W-20 // 4. Influenza Virus W-40 // ‘Chapter 34 Eukaryotic Gene Expression // 1. Chromosome Structure // 2. Genomic Organization // 3. Control of Expression // 4. Cell Differentiation // ‘Chapter 35 Molecular Physiology // 1. Blood Clotting // 2. Immunity // 3. Motility: Muscles, Vesicle Transport, // Cilia, and Flagella // Index ? // *Chapiers 33, 34, and 35 are available on our book companion website, www.wiley.com/college/voet.