.

0 (hodnocen0 x )

BK

First published

Cambridge : Cambridge University Press, 2012

xvi, 298 stran : ilustrace ; 25 cm

ISBN 978-0-521-17216-5 (brožováno)

Obsahuje bibliografie a rejstřík

Popsáno podle dotisku z roku 2016

001458391

Contents // Acknowledgments page xi // Introduction xiii // The energy around us 1 // 1.1 Forms of energy 1 // 1.2 Ambient energy 3 // 1.3 Molecular energy 5 // 1.4 Molecular energy absorbance 6 // 1.5 Molecular transduction 7 // 1.6 Ionizing radiation 9 // 1.7 Magnetic resonance 11 // 1.8 Sound 16 // Molecular contacts 21 // 2.1 Dissociation constants 21 // 2.2 Promotor sites and autoimmune diseases 24 // 2.3 Methods of measuring dissociation constants 30 // 2.4 Metal-molecular coordination bonds 33 // 2.5 Hydrogen bonds 37 // 2.6 Non-bonded molecular interactions 43 // Diffusion and directed transport 50 // 3.1 Forces and flows 50 // 3.2 Fick’s laws of diffusion 55 // 3.3 Brownian motion 58 // 3.4 Physiological diffusion of ions and molecules 60 // 3.5 Molecular motors 68 // 3.6 Intracellular cargo transport 76 // Vlil // Contents // 8 // I // 9 // 88 // S: // 33 // a;: // s // i // 8 // 4 Energy production 80 // 4.1 Energetics of human performance 80 // 4.2 ATP, ADP and Pi 82 // 4.3 Phosphocreatine 86 // 4.4 Glycolysis 90 // 4.5 Mitochondria " 92 // 5 Force and movement 97 // 5.1 The skeletal length-tension relation 97 // 5.2 Muscle contractions after windup 100 // 5.3 Cardiac and smooth muscle length-tension relations 101 // 5.4 The Hill formalism of the crossbridge cycle 103 // 5.5 Muscle shortening, lengthening and power 105 // 5.6 Calcium dependence of muscle velocity 110 // 5.7 Smooth muscle latch 113 // 5.8 Muscle tension transients 114 // 5.9 The Law of Laplace

for hollow organs 116 // 5.10 Non-muscle motility 119 // 6 Load bearing 123 // 6.1 Stress and strain 123 // 6.2 Teeth and bone 125 // 6.3 Bloodvessels 130 // 6.4 Tendons, ligaments and cartilage 138 // 7 Fluid and air flow 144 // 7.1 Fluid properties 144 // 7.2 Synovial fluid flow 150 // 7.3 Arterial blood flow 151 // 7.4 Arteriole blood flow 154 // 7.5 Viscosity and hematocrit 157 // 7.6 Arterial stenosis 160 // 7.7 Arterial asymmetry: atherosclerosis and buckling 162 // 7.8 Lung air flow 165 // 8 Biophysical interfaces: surface tension and membrane structural properties 169 // 8.1 Surface tension 169 // 8.2 Action of surfactant on lung surface tension 174 // 8.3 Membrane lipids 175 // 8.4 Membrane curvature 177 // 8.5 Membrane protein and carbohydrate environment 179 // Contents ix // sessesmesscesseessseseessssssswenseesseeseezsseesssessssesseeeeceesneeswssesssssesssesssssesssessssessseosecerrsesesnnesssceseenseessemresessesecesseseeeesxsssseeerssesesrsesersssseseressceesceeseesseerseesesessxesssceossessseesesserneemreeeseceseeeeseesssesssesssessesseesssenme880mcmm222888898888888 5880888/889888998088000800888888908890888088888880883018888888881993883008888888088898830/83018008888808889980820209920090008308800888888% // 8.6 Membrane protein transporters 182 // 8.7 Membrane organization 187 // 8.8 Ultrasonic pore formation 191 // 8.9 Membrane diffusion and viscoelasticity 192 // 8.10 Membrane ethanol effects 195 // Membrane electrical properties 199 // 9.1 Membrane potential

199 // 9.2 Goldman and Nernst equations 203 // 9.3 The dielectric constant of water and water surface binding 206 // 9.4 Induced dipole orientation in solution 208 // 9.5 Membrane electric field complex dissociation 211 // 9.6 Membrane electrical conductance 217 // 9.7 The electrocardiogram 221 // 9.8 Channel ion selectivity 223 // Agonist activation and analysis 230 // 10.1 Membrane receptor proteins 230 // 10.2 Pharmacokinetics 233 // 10.3 The dose-response curve and the Hill equation 239 // 10.4 Intracellular molecular diffusion and elimination 240 // 10.5 Statistical analysis 245 // 10.6 Drug development and orphan diseases 251 // Stability, complexity and non-linear systems 256 // 11.1 System control 257 // 11.2 Negative feedback and metabolic control 260 // 11.3 Positive feedback 264 // 11.4 Models of state stability 267 // 11.5 State transitions 269 // 11.6 Non-linear systems: fractals and chaos 274 // 11.7 Apoptosis 281 // Concluding remarks 285 // Index // 286