BRIEF CONTENTS // Part I THE MOLECULAR DESIGN OF LIFE // 1 Biochemistry: An Evolving Science 1 // 2 Protein Composition and Structure 27 // 3 Exploring Proteins and Proteomes 65 // 4 DNA, RNA, and the Flow of Genetic Information 105 // 5 Exploring Genes and Genomes 135 // 6 Exploring Evolution and Bioinformatics 169 // 7 Hemoglobin: Portrait of a Protein in Action 191 // 8 Enzymes: Basic Concepts and Kinetics 215 // 9 Catalytic Strategies 251 // 10 Regulatory Strategies 285 // 11 Carbohydrates 315 // 12 Lipids and Cell Membranes 341 // 13 Membrane Channels and Pumps 367 // 14 Signal-Transduction Pathways 397 // Part II TRANSDUCING AND STORING ENERGY // 15 Metabolism: Basic Concepts and Design 423 // 16 Glycolysis and Gluconeogenesis 449 // 17 The Citric Acid Cycle 495 // 18 Oxidative Phosphorylation 523 // 19 The Light Reactions of Photosynthesis 565 // 20 The Calvin Cycle and the Pentose Phosphate Pathway 589 // 21 Glycogen Metabolism 617 // 22 Fatty Acid Metabolism 643 // 23 Protein Turnover and Amino Acid Catabolism 681 // Part III SYNTHESIZING THE MOLECULES OF LIFE // 24 The Biosynthesis of Amino Acids 713 // 25 Nucleotide Biosynthesis 743 // 26 The Biosynthesis of Membrane Lipids and Steroids 767 // 27 The Integration of Metabolism 801 // 28 DNA Replication, Repair, and Recombination 827 // 29 RNA Synthesis and Processing 859 // 30 Protein Synthesis 893 // 31 The Control of Gene Expression in Prokaryotes 925 // 32 The Control of Gene Expression in Eukaryotes 941 // Part IV RESPONDING TO ENVIRONMENTAL CHANGES // 33 Sensory Systems 961 // 34 The Immune System 981 // 35 Molecular Motors 1011 // 36 Drug Development 1033