Part I- Cell Replacement Therapy -- 1. Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cell Transplantation for Retinal Degeneration -- 2. Stem Cell-Derived RPE transplantation: the feasibility and advantages of delivery as monolayers -- 3. Induced Pluripotent Stem Cell-Derived Autologous Cell Therapy for Age-related Macular Degeneration -- 4. Scaffolds for Cell Transplantation -- 5. Surgical Approaches for Cell Transplantation in Cell Replacement Therapy -- 6. Cell Transplantation Therapy for Glaucoma. Part II - Cell-based Neuroprotection -- 7. Autologous Bone Marrow-Derived Cell Therapies for Retinal Disease -- 8. Subretinal Delivery of Cells Via the Suprachoroidal Space: The Janssen Trial. Part III – Disease Modeling using Induced Pluripotent Stem Cells -- 9. “Disease in a Dish” Modeling of Retinal Diseases -- 10. Retinal Organoids: An Emerging Technology for Retinal Disease Research and Therapy.
This book familiarizes the reader with the current landscape of cell-based therapies for the treatment of retinal disease, including diseases that affect the choriocapillaris, retinal pigment epithelium, photoreceptors, and retinal ganglion cells. Instead of utilizing a disease-centric approach to the topic, this book—edited by world-renowned stem cell scientists—focuses on strategies for developing and transplanting the cells. This includes the creation of replacement cells, cell-based neuroprotection, and in vitro disease modeling and testing. The final chapters briefly review parallel approaches that do not directly utilize cellular transplantation. The use of cellular transplantation to treat retinal disease has recently become a viable and exciting therapeutic approach. The visibility of the retina and its laminar cellular architecture render it an ideal organ for the development of surgically delivered cellular therapies. Having an in-depth understanding of the current state of cell therapy for the eye is an essential first step toward utilizing similar approaches in other organs. Ophthalmologists, translational clinician-scientists, stem cell scientists, and researchers interested in eye disease will find Cellular Therapies for Retinal Disease: A Strategic Approach essential reading and it is also suitable for workshops or courses at the undergraduate or Ph.D. level..