PART I Ashwagandha - Phytogenomics and Pharmacology -- Phytochemical Genomics of Ashwagandha -- Phyto-pharmacology of Ashwagandha as An Anti-Diabetic Herb -- Allium cepa Root Chromosomal Aberration Assay: An Application in Assessing Anti-genotoxic Potential of Ashwagandha -- Withania somnifera: From Traditional Use to Evidence Based Medicinal Prominence -- Withanolides: A Prospective Drug for Infectious and Tropical Diseases -- Withania somnifera Extract/Withaferin A As A Prospective Anti-pigmenting Agent -- PART II Ashwagandha for Cancer -- Ashwagandha Bioactives for Cancer Treatment: Experimental Evidence and Their Mechanism(s) of Action -- Scientific Evidence for Anticancer Effects of Withania somnifera And its Primary Bioactive Component Withaferin A -- Withaferin A for Cancer Treatment: Experimental Evidence for its Effect on Telomerase Plus and Minus Cancer Cells -- Withania somnifera Has Potential to Treat Cancer ---
The Effects of Withaferin A on Normal And Malignant Immune Cells -- Ashwagandha for Cancer Metastasis: Bioactives and Basics of their Function -- Computational Methods to Understand The Anticancer Mechanism of Withanolides -- PART III Ashwagandha for Brain -- Ashwagandha for Brain Health: Experimental Evidence to its Neuroregenerative Activities -- Cellular and Molecular Targets Underpinning Memory Enhancement by Ashwagandha -- Using Human Neural Stem Cells as A Model to Understand The Science of Ashwagandha -- The Potential Utility of Ashwagandha for Improving Cognitive Dysfunction in Persons with Bipolar or Other Neurocognitive Disorders -- Neuroprotective Potential of Withania somnifera (Ashwagandha) in Neurological Conditions -- Potential Therapeutic Use of Withania somnifera for Treatment of Amyotrophic Lateral Sclerosis -- Neuromodulatory Role of Withania somnifera -- Therapeutic Effects of Ashwagandha in Brain Aging and Clock Disfunction ---
PART IV Active Ingredient Enriched Ashwagandha - Biotechnologies -- Biotechnological Approaches in Propagation And Improvement of Withania somnifera (L.) Dunal -- Plant Tissue Culture Based Strategies for Production of Withanolides -- Establishment of Hydroponic Cultivation of Ashwagandha for Active Ingredient Enriched Leaves.
Rapidly increasing aging population and environmental stressors are the two main global concerns of increasing incidence of a variety of pathologies in the modern society. The complex etiologies and pathologies cause major challenges to disease treatment. On the other hand, several herbs are known for their health-caring and disease-curing activities. Ashwagandha, a popular herb in Indian traditional home medicine, Ayurveda, has gathered increasing recognition in recent years when the chemically synthesized drugs for single target therapies showed limited success and adverse toxic effects. Ashwagandha is known as a powerful adaptogen and trusted to enhance function of the brain, reproductive system, cell-mediated immunity and increase the body’s defense against disease, and possess anti-inflammatory, anticancer and anti-arthritic activities. In this book, for the first time, we provide a complete portrait on scientific understanding of the effects of Ashwagandha and its active principles for a variety of preventive and therapeutic activities..