Part I. Adipose Tissue Biology and Crosstalks -- 1. Function and Dysfunction of Adipose Tissue -- 2. The Role of Brain in Energy Balance -- 3. Neuroendocrinology of Adipose tissue and Gut-Brain Axis -- Part II. Obesity as a Risk Factor for Neurological Disease -- 4. Hypothalamic Dysfunction in Obesity and Metabolic Disorders -- 5. Diabesity and Brain Energy Metabolism: The case of Alzheimer’s Disease -- 6. The Influence of Adipose Tissue on Brain Development, Cognition and Risk of Neurodegenerative Disorders -- 7. Cerebrovascular Disease: Consequences of Obesity-Induced Endothelial Dysfunction -- 8. Multiple Sclerosis: Implications of Obesity in Neuroinflammation -- Part III. Brain Function after Bariatric Surgery -- 9. Central Modulation of Energy Homeostasis and Cognitive Performance after Bariatric Surgery -- Part IV. Neuroimaging in obesity -- 10. Functional Neuroimaging in Obesity Research.
This compendium provides a wide view covering everything from molecular mechanisms and risk factors for neurological disorders to the effects of bariatric surgery on brain function and functional neuroimaging applied to obesity research. The impact of obesity on brain function and the development of neurodegenerative and neuroinflammatory disorders has been understudied, despite the recent proliferation of obesity research. Among the topics covered are adipose biology, the adipose tissue - gut - brain axis, brain energy metabolism, dementia, cerebrovascular disease, and multiple sclerosis..