Part 1. Introduction -- 1. Epidemiology and metabolic/hormonal influences -- 2. Pathology -- 3. Clinical behavior and treatment -- Part 2. Molecular Profiling -- 4. Traditional approaches -- 5. Next generation sequencing -- 6. Specific Pathways -- Part 3. Mouse models -- 7. Pten -- 8. Mig-6 -- 9. Lkb -- Part 4. 10. Future Directions -- Index.
This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma..