Building on the previous edition with contributions from internationally renowned experts this book provides a fully comprehensive resource for managing the post emergency/treatment stage of acute poisoning. Chapters incorporate evidence-based paradigms with up-to-date citations from the original medical literature. Topic areas covered include: diagnosis and management of the critically poisoned patient, including pediatric patients and poisoning in pregnancy; toxic syndromes including hepatotoxic and pulmonary syndromes as well as poisonings from medications, drugs of abuse, chemical and biological agents. This book is an essential resource for Clinical Toxicologists, Intensivists and Emergency Medicine specialists in training and in practice..
Volume 1 // Part I General Management of the Critically Poisoned Patient // 1 The Critically Poisoned Patient ...3 // J. Ward Donovan, Keith Burkhart, and Jeffrey Brent // 2 The Diagnostic Process in Medical Toxicology ...29 // Anthony F. Pizon, Joseph H. Yanta, and // Greg S. Swartzentruber // 3 Therapeutic Approach to the Critically Poisoned Patient ...43 // Evan S. Schwarz // 4 Extracorporeal Membrane Oxygenation and // Cardiopulmonary Bypass in the Poisoned Patient ...79 // William P. Kerns II and Alan C. Heffner // 5 Post-Resuscitation Management of the Poisoned Patient ...101 // Michael Lynch and Jon C. Rittenberger // 6 Psychiatric Issues in the Critically Poisoned Patient ...117 // J. J. Rasimas and Gregory L. Carter // 7 Poisoning in Pregnancy ...159 // Kevin F. Maskell Jr., Kirk L. Cumpston, // Timothy B. Erickson, and Jerrold B. Leikin // 8 Geriatric Poisoning 193 // Janetta L. Iwanicki // 9 Intensive Care of Pediatric Poisoning Cases ...205 // Prashant Joshi and Mitchell P. Ross // 10 The Critically Poisoned Worker ...223 // Michael G. Holland // 11 Complications of Chronic Alcoholism That Affect // Critical Illness ...249 // Alison L. Jones // 12 Extracorporeal Substance Removal ...267 // Monique J. Cormier and Marc Ghannoum // 13 Poisoning Fatalities ...279 // Philippe E. Hantson // Part II Toxic Syndromes ...293 // 14 The Assessment and Management of Hypotension // and Shock in the Poisoned Patient ...295 // Florian Eyer // 15 Acid-Base Balance in the Poisoned Patient ...325 // Stephen W. Borron // 16 Treatment of Acute Respiratory Distress Syndrome // in the Poisoned Patient ...359 // Dylan W. de Lange // 17 Toxicant-Induced Hepatic Injury ...385 // Kim Dalhoff // 18 Toxicant-Induced Renal Injury ...409 // Joshua D. King // 19 Toxicant-Induced Alterations in Consciousness ...425 // Jerrold B. Leikin and Andrea Carlson //
20 Toxicant-Induced Seizures ...447 // Philippe E. Hantson // 21 Cardiac Conduction and Rate Disturbances ...475 // Hallam Gugelmann and Neal Benowitz // 22 Toxicant-Induced Torsade de Pointes ...509 // Jonas Höjer and Donna Seger // 23 Anticholinergic Syndrome ...519 // William J. Boroughf // 24 Serotonin Syndrome ...539 // Peter R. Chai and Edward W. Boyer // 25 Sympathomimetic Syndrome ...549 // Andrew M. King, Eric R. Malone, and Cynthia K. Aaron // 26 Toxicant-Induced Immunological Reactions ...569 // Jenny M. Stitt and Stephen C. Dreskin // 27 Withdrawal Syndromes ...591 // Adhi N. Sharma and Robert S. Hoffman // 28 Acute Radiation Injuries ...605 // Ziad N. Kazzi // 29 Malignant Hyperthermia ...619 // Henry Rosenberg, Dorothea Hall, and Harvey Rosenbaum // 30 Toxicant-Induced Hematologic Syndromes ...643 // Steven C. Curry and A. Min Kang // 31 Neuroleptic Malignant Syndrome ...661 // Rebecca E. Bruccoleri and Michael J. Burns // 32 Toxicant-Induced Rhabdomyolysis ...679 // G. Patrick Daubert // Part III Medication // Safety in the Intensive Care Unit ...691 // 33 Adverse Drug Reactions in the Intensive Care Unit ...693 // Philip Moore and Keith Burkhart // 34 Medication Errors and Drug-Drug Interactions in the // Intensive Care Unit ...741 // Brenna Farmer and Luke Yip // Part IV Medications: Cardiovascular ...749 // 35 Alpha-2 Adrenergic and Imidazoline Receptor // Agonists: Clonidine, Dexmedetomidine, and Related // Antihypertensives, Decongestants, and Sedatives ...751 // Anthony J. Tomassoni // 36 Beta-Receptor Antagonists ...771 // Michael Levine and Jeffrey Brent // 37 Calcium Channel-Blocking Agents ...787 // Maude St-Onge and Jeffrey Brent // 38 Digitalis Glycosides ...807 // Bruno Megarbane // 39 Sodium Channel-Blocking Antidysrhythmics ...821 // Silas W. Smith // 40 Sodium Nitroprusside ...843 // Steven C. Curry and Meghan B. Spyres //
41 Sympathomimetic Agents ...851 // Robert J. Hoffman and Lewis S. Nelson // Part V Medications: Decongestant/Antihistaminergic/ // Bronchodilatory ...867 // 42 Antihistamines ...869 // Jerry W. Snow and R. Brent Furbee // 43 Theophylline and Other Methylxanthines ...883 // Ann-Jeannette Geib // Part VI Medications: Psychotropic ...905 // 44 Antipsychotics ...907 // Bradley L. Demeter and Michael J. Burns // 45 Anxiolytics, Sedatives, and Hypnotics ...935 // C. William Heise and Daniel E. Brooks // 46 Barbiturates ...955 // Steven J. Walsh and Kenneth D. Katz // 47 Bupropion ...965 // Peter Wu and David Juurlink // 48 Cyclic Antidepressants ...975 // Mark K. Su // 49 Lithium ...991 // Eric J. Lavonas and Jeffrey Brent // 50 Monoamine Oxidase Inhibitors ...1009 // Aym D. O’Connor and Kirk C. Mills // 51 Serotonergic Antidepressants ...1027 // Andrew H. Dawson // Volume 2 // Part VII Medications: Anticonvulsant ...1041 // 52 Hydantoin Anticonvulsants: Phenytoin and // Fosphenytoin ...1043 // Frank LoVecchio // 53 Iminostilbene Anticonvulsants: Carbamazepine and // Oxcarbazine ...1053 // Hwee Min Lee and Andis Grandins // 54 Second Generation Anticonvulsants: Gabapentin, // Lamotrigine, Levetiracetam, and Topiramate ...1065 // M. P. Emswiler and Kirk L. Cumpston // 55 Valproic Acid ...1083 // Wayne R. Snodgrass and Chia Wei Hsu // Part VIII Medications: Neuromuscular ...1095 // 56 Antiparkinsonian Agents ...1097 // Steven J. Walsh and Kenneth D. Katz // 57 Baclofen ...1119 // Erin Stewart and Laura M. Tormoehlen // 58 Centrally Acting Muscle Relaxants ...1133 // Madeline L. McCarthy and Carl R. Baum // Part IX Medications: Analgesic/Anti-Inflammatory ...1143 // 59 Acetaminophen/Paracetamol ...1145 // D. Nicholas Bateman // 60 Methotrexate ...1171 // Yedidia Bentur and Yael Lurie // 61 Nonsteroidal Anti-Inflammatory Drugs ...1219 // Kimberlie A. Graeme //
62 Opioids ...1237 // Scott Lucyk and Lewis S. Nelson // 63 Salicylates ...1251 // Steven C. Curry and Meghan B. Spyres // Part X Medications: Antimicrobial ...1269 // 64 Chloroquine and Quinine ...1271 // Alison L. Jones // 65 Isoniazid and Related Hydrazines ...1287 // Cynthia Koh, Alicia B. Minns, and Richard F. Clark // 66 Rifampin, Dapsone, and Vancomycin ...1299 // Cyrus Rangan and Richard F. Clark // Part XI Medications: Hematologic ...1311 // 67 Iron ...1313 // Sean M. Bryant and Jerrold B. Leikin // 68 Oral Anticoagulants ...1325 // George Sam Wang // 69 Thrombolytics, Heparin and Derivatives, // and Antiplatelet Agents ...1341 // Robert A. Raschke and Steven C. Curry // Part XII Medications: Miscellaneous ...1361 // Antidiabetic Agents ...1363 // Jenna M. LeRoy and Samuel J. Stellpflug // Antitubulin Agents: Colchicine, Vinca Alkaloids, and // Podophyllin ...1387 // Jerry W. Snow, Louise W. Kao, and R. Brent Furbee // XIII Drugs of Abuse ...1411 // Amphetamines and Their Derivatives ...1413 // Nicholas J. Connors and Robert S. Hoffman // Arylcyclohexamines: Ketamine, Phencyclidine, and // Analogues ...1439 // James H. Ho and Paul I. Dargan // Cathinones ...1485 // Rachelle Abouchedid and David M. Wood // Cocaine ...1525 // Ruben Olmedo, Christopher Yates, and Robert S. Hoffman // Gamma-Hydroxybutyrate and Its Related Analogues // Gamma-Butyrolactone and 1,4-Butanediol ...1555 // David M. Wood // Hallucinogens ...1587 // Curtis P. Snook // Synthetic Cannabinoid Receptor Agonists ...1609 // Andrew A. Monte // XIV Chemical Agents: Metals and Related Substances ...1617 // Antimony and Nickel ...1619 // Matthew D. Sztajnkrycer // Arsenic ...1639 // Michael J. Kosnett // Cadmium ...1669 // Jan Meulenbelt // Lead ...1675 // Michael J. Kosnett // Mercury ...1705 // Irma de Vries // 84 Phosphorus ...1719 // Emily B. Austin and Marco L. A. Sivilotti //
85 Thallium ...1733 // Sean H. Rhyee // Part XV Chemical Agents: Solvents, Glycols, and Alcohols ...1741 // 86 Ethylene Glycol and Other Glycols ...1743 // Knut Erik Hovda, Kenneth McMartin, and Dag Jacobsen // 87 Isopropyl Alcohol ...1761 // Heath A. Jolliff // 88 Methanol and Formaldehyde ...1769 // Knut Erik Hovda, Kenneth McMartin, and Dag Jacobsen // Part XVI Chemical Agents: Pesticides ...1787 // 89 Chlorophenoxy Herbicides ...1789 // Sally M. Bradberry and J. Allister Vale // 90 Fumigants ...1797 // Matthew Zuckerman // 91 Fungicides ...1811 // Annette M. Lopez and Daniel Sudak in // 92 Organophosphate and Carbamate Insecticide ...1829 // J. Allister Vale and Sally M. Bradberry // 93 Paraquat and Diquat ...1855 // Michael Eddleston // 94 Phosphate and Phosphine ...1875 // Ashish Bhalla // 95 Rodenticides ...1887 // Ryan Chuang and Jennie A. Buchanan // Part XVII Chemical Agents: Gases and Vapors ...1909 // 96 Carbon Monoxide ...1911 // Christopher Hoyte // 97 Cyanide: Hydrogen Cyanide, Inorganic Cyanide Salts, and // Nitriles ...1929 // Steven C. Curry and Meghan B. Spyres // 98 Hydrocarbons and Halogenated Hydrocarbons ...1951 // Jakub Furmaga, Kurt Kleinschmidt, and Kapil Sharma // 99 Hydrogen Sulfide ...1963 // Aaron Skolnik and C. William Heise // 100 Irritant and Toxic Pulmonary Injuries ...1973 // Joseph K. Maddry // Part XVIII Chemical Agents: Caustics and Corrosives ...2003 // 101 Caustics ...2005 // Diane P. Calello // 102 Hydrofluoric Acid ...2021 // Kennon Heard // Volume 3 // Part XIX Natural Toxins: Marine ...2031 // 103 Ciguatera ...2033 // Shaun Greene // 104 Marine Vertebrates, Cnidarians, and Mollusks ...2045 // L. Keith French and B. Zane Horowitz // 105 Scombroid ...2075 // Mark A. Suguitan and Rama B. Rao // 106 Tetrodotoxin ...2085 // Chen-Chang Yang // Part XX Natural Toxins: Mushrooms ...2101 //
107 Overview of Mushroom Poisoning ...2103 // Michael C. Beuhler // 108 Cyclopeptide-Containing Mushrooms: 1 he Deadly // Amanitas ...2129 // Thomas Zilker and Heinz Faulstich // 109 Gyromitra Mushrooms ...2149 // Daniel E. Brooks and Kimberlie A. Graeme // Part XXI Natural Toxins: Plants and Herbals ...2161 // 110 Overview of Plant and Herbal Toxicity ...2163 // Philip Aplin // 111 Anticholinergic Plants ...2175 // Robert N. E. French and Frank G. Walter // 112 Cardiotoxic Plants ...2187 // Barbarajean Magnani and Alan D. Woolf // 113 Poison Hemlock ...2205 // Frederick W. Fiesseler and Richard D. Shih // 114 Toxalbumins ...2213 // Jennifer A. Oakes and Richard Y. Wang // 115 Water Hemlock ...2225 // Edward W. Cetaruk // Part XXII Natural Toxins: Scorpions ...2237 // 116 Overview of Scorpion Envenoming ...2239 // Julian White // 117 Middle East and North African Scorpions ...2255 // Yona Amitai // 118 North American Scorpions ...2269 // Michael Levine and Anne-Michelle Ruha // Part XXIII Natural Toxins: Snakes ...2277 // 119 Overview of Snake Envenoming ...2279 // Julian White // 120 African Snakes ...2319 // Jean-Philippe Chippaux, Julian White, and // Abdulrazaq G. Habib // 121 Asian Snakes ...2343 // Aniruddha Ghose and Julian White // 122 Australian and Pacific Snakes ...2405 // Julian White // 123 European Snakes ...2441 // Luc de Haro and David Boels // 124 Non-Front-Fanged Colubroid Snakes ...2453 // Scott A. Weinstein // 125 North American Coral Snakes and Related Elapids ...2493 // Jeffrey N. Bernstein // 126 Rattlesnakes and Other North American Crotalids ...2503 // Anne-Michelle Ruha // 127 South and Central American Snakes ...2527 // Ceila Maria Sant’Ana Malaque and Jose Maria Gutierrez // Part XXIV Natural Toxins: Spiders ...2549 // 128 Overview of Spider Envenoming ...2551 // Julian White // 129 Australian Funnel Web Spiders ...2565 // Julian White //
130 Loxosceles Spiders ...2577 // Ceila Maria Sant’Ana Malaque, Richard S. Vetter, and // Marlene Entres // 131 Widow and Related Lactrodectus Spiders ...2595 // Jeena Jacob and Julian White // Part XXV Natural Toxins: Miscellaneous ...2607 // 132 Botulism ...2609 // B. Zane Horowitz // 133 Massive Bee Envenomation ...2627 // Hui Wen Fan and Jorge Kalil // Part XXVI Threat Agents ...2637 // 134 Chemical Terrorism Incidents and Intensive Care ...2639 // R. Steven Tharratt and Timothy E. Albertson // 135 Nerve Agents ...2655 // Mahdi Balali-Mood, Beeta Balali-Mood, and // Kia Balali-Mood // 136 Sulfur Mustard ...2683 // Dirk Steinritz and Horst Thiermann // Part XXVII Antidotes ...2713 // 137 Antidigitalis Fab Fragments ...2715 // Bruno Megarbane // 138 Atropine ...2725 // Robert N. E. French and Frank G. Walter // 139 Calcium Edetate (Calcium Disodium EDTA) ...2733 // Michael J. Kosnett // 140 Cyanide-Binding Antidotes: Dicobalt Edetate and // Hydroxocobalamin ...2737 // Vikhyat S. Bebarta // 141 Cyproheptadine ...2747 // Karen E. Simone // 142 Dantrolene ...2757 // Blaine E. Benson // 143 Deferoxamine ...2771 // F. Lee Cantrell // 144 4-Dimethylamino Phenol ...2779 // Thomas Zilker and Peter Eyer // 145 Dimercaprol ...2791 // Michael J. Kosnett // 146 Ethanol ...2795 // Tammi H. Schaeffer // 147 Euglycemic Insulin Therapy ...2801 // Kristin Engebretsen // 148 Flumazenil ...2811 // Allyson Kreshak and Stephen Munday // 149 Folic and Folinic Acids ...2819 // Michelle A. Hieger and S. Rutherfoord Rose // 150 Fomepizole ...2829 // Kenneth McMartin, Knut Erik Hovda, and Dag Jacobsen // 151 Immunotherapy ...2843 // Steven A. Seifert and Brandon J. Warrick // 152 Lipid Resuscitation Therapy ...2859 // Jeffrey Brent and Michael Levine // 153 Methylene Blue ...2867 // Jack Clifton II and Jerrold B. Leikin // 154 Acetylcysteine ...2879 // Eric Villeneuve and Sophie Gosselin //
155 Nitrites ...2889 // Bruce D. Anderson // 156 Octreotide ...2897 // Bryan D. Hayes // 157 Opioid Receptor Antagonists ...2907 // Scott Lucyk and Lewis S. Nelson // 158 Oximes ...2913 // J. Allister Vale // 159 D-Penicillamine ...2929 // Cristy Eidelman and Jennifer A. Lowry // 160 Pentetic Acid ...2937 // Shikha Kapil and Ziad N. Kazzi // 161 Physostigmine ...2943 // William J. Boroughf // 162 Prussian Blue ...2957 // Pierre-Andre Dube and Sophie Gosselin // 163 Pyridoxine ...2963 // Ashleigh Kennedy and Tammi H. Schaeffer // 164 Sodium Bicarbonate ...2967 // Sara K. Lookabill, Anna Rouse Dulaney, // Greene Shepherd, and William P. Kerns II // 165 Succimer ...2987 // Michael J. Kosnett // 166 Thiamine ...2993 // Alfred Aleguas Jr. // 167 Thiosulfate ...3001 // F. Lee Cantrell // 168 Unithiol ...3005 // Michael J. Kosnett // Erratum to: Critical Care Toxicology - Diagnosis and // Management of the Critically Poisoned Patient ...El // Jeffrey Brent, Keith Burkhart, Paul Dargan, Benjamin Hatten, // Bruno Megarbane, Robert Palmer, and Julian White // Appendix: Sympathomimetic Pressors ...3009 // Jeffrey Brent // Grading System for Levels of Evidence Supporting // Recommendations in Critical Care Toxicology, 2nd Edition ...3017 // Index ...3019