Calcium channels and pumps important during lactation as potential targets for breast cancer -- Tumor development through the Mg2+nifying glass -- Selenium: roles in cancer prevention and therapies -- Zinc and Zinc-Dependent Proteins in Cancer adn Chemotherapeutics -- Arsenic Carcinogenesis -- Cadmium Carcinogenesis and Mechanistic Insights -- Molecular Mechanisms of Chromium-Induced Carcinogenesis -- Mechanisms of Nickel Carcinogenesis -- Application of Metallomics and Metalloproteomics for Understanding the Molecular Mechanisms of Action of Metal-based Drugs.
This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, Iron, copper and Zinc) and non-essential metals (Nickel, Chromium, Cadmium and Arsenic, Tungsten and Asbestos). Each chapter will have a dedicated section focusing on the binary role that some of these metals play, their carcinogenic and cancer therapeutics, by integrating epidemiological, experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS, kinase families, receptors, endoplasmic, mitochondrial players and epigenetics. As part of integrating the human, experimental and mechanistic data, as well as a detailed analysis into the modes of action for different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do..