CONTENTS // CHAPTER 1 CHAPTER 2 CHAPTER 3 CHAPTER 4 CHAPTER 5 CHAPTER 6 // CHAPTER 7 CHAPTER 8 CHAPTER 9 CHAPTER 10 CHAPTER 11 CHAPTER 12 CHAPTER 13 CHAPTER 14 // CHAPTER 15 CHAPTER 16 CHAPTER 17 CHAPTER 18 CHAPTER 19 CHAPTER 20 CHAPTER 21 // Properties and Overview of Immune Responses 1 Cells and Tissues of the Immune System 13 Leukocyte Circulation and Migration into Tissues 39 Innate Immunity 57 Antibodies and Antigens 97 // Antigen Presentation to T Lymphocytes and the Functions of Major Histocompatibility Complex Molecules 117 // Immune Receptors and Signal Transduction 145 // Lymphocyte Development and Antigen Receptor Gene Rearrangement 179 // Activation of T Lymphocytes 209 // Differentiation and Functions of CD4+ Effector T Cells 225 // Differentiation and Functions of CD8+ Effector T Cells 243 // ? Cell Activation and Antibody Production 251 // Effector Mechanisms of Humoral Immunity 275 // Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues 299 // Immunologic Tolerance and Autoimmunity 325 Immunity to Microbes 351 Transplantation Immunology 373 Immunity to Tumors 397 Hypersensitivity Disorders 417 Allergy 437 // Congenital and Acquired Immunodeficiencies 459 // x // Contents // Glossary 489 Appendices // I Cytokines 519 // II Principal Features of Selected CD Molecules 523 // III Laboratory Techniques Commonly Used in Immunology 531