PART I AN INTRODUCTION TO IMMUNOBIOLOGY AND INNATE IMMUNITY Chapter 1 Basic Concepts in Immunology 1 // Chapter 2 Innate Immunity: The First Lines of Defense 37 // Chapter 3 The Induced Response of Innate Immunity 77 // PART II THE RECOGNITION OF ANTIGEN // Chapter 4 Antigen Recognition by B-cell and T-cell Receptors 139 // Chapter 5 The Generation of Lymphocyte Antigen Receptors 173 // Chapter 6 Antigen Presentation to T Lymphocytes 213 // PART III THE DEVELOPMENT OF MATURE LYMPHOCYTE RECEPTOR REPERTOIRES // Chapter 7 Lymphocyte Receptor Signaling 257 // Chapter 8 The Development of B and T Lymphocytes 295 // PART IV THE ADAPTIVE IMMUNE RESPONSE // Chapter 9 T-cell-Mediated Immunity 345 // Chapter 10 The Humoral Immune Response 399 // Chapter 11 Integrated Dynamics of Innate and Adaptive Immunity 445 // Chapter 12 The Mucosal Immune System 493 // PART V THE IMMUNE SYSTEM IN HEALTH AND DISEASE // Chapter 13 Failures of Host Defense Mechanisms 533 // Chapter 14 Allergy and Allergic Diseases 601 // Chapter 15 Autoimmunity and Transplantation 643 // Chapter 16 Manipulation of the Immune Response 701 // APPENDICES // I The Immunologist’s Toolbox 749 // II CD antigens 791 // III Cytokines and their Receptors 811 // IV Chemokines and their Receptors 814 // Biographies // Index 855