Since publication of the 4th Edition of The Autoimmune Diseases in 2006, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This fully revised 5th Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels and includes expanded coverage of autoinflammatory disease..
Immunologic basis of autoimmunity. Autoimmune disease : the consequence of disturbed homeostasis / Noel R. Rose and ian R. Mackay. Autoimmunity : a history of the early struggle for recognition / Arthur M. Silverstein. General features of autoimmune disease / Anne Davidson and Betty Diamond. The concept of autoinflammatory diseases / Monique Stoffels and Anna Simon -- Immune cells and immune responses. Innate and adaptive systems of immunity / Peter J. Delves. T cells and their subsets in autoimmunity / Patrick R. Burkett ... [and 3 others]. Immunological tolerance-T cells . Sara R. Hamilton, Sarah Q. Crome, and Pamela S. Ohashi. The role of invariant natural killer T cells in autoimmune diseases / Gerhard Wingender and Mitchell Kronenberg. B cell development : how to become one of the chosen ones / Fritz Melchers. B cell activation and B cell tolerance / Claudia Mauri, Venkat Reddy, and Paul A. Blair --- Non-antigen-specific recognition. Role of macrophages in autoimmunity / Siamon Gordon and Annette Plüddemann. Dendritic cells in autoimmune disease / Kristen Radford, Ken Shortman, and Meredith O’Keeffe. Natural killer cells / Yenan T. Bryceson ... [and 3 others]. Granulocytes : neutrophils, basophils, eosinophils / Xavier Bosch and Manuel Ramos-Casals. The roles and contributions of the complement system in the pathophysiology of autoimmune diseases / Wilhelm J. Schwaeble, Youssif M. Ali, and Robert B. Sim. Cytokines, their receptors and signals / Joost J. Oppenheim --- Initiation of autoimmunity. Cellular injury and apoptosis / Stefania Gallucci, Roberto Caricchio, and Philip L. Cohen. Autophagy in autoimmunity / Jan Lünemann and Christian Münz. Infectious triggers of T cell autoimmunity / Daniel R. Getts ... [and 3 others].
Autoimmune diseases : the role for vaccines / S. Sohail Ahmed and Paul-Henri Lambert. Non-infectious environmental agents and autoimmunity / Frederick W. Miller. Adhesion molecules and chemoattractants in autoimmunity / Charles R. Mackay and Ulrich H. von Andrian --- Facilitation of autoimmunity. Effector mechanisms in autoimmunity / Arian Laurence and Martin Aringer. Sexual dimorphism in the immune system / Pamela A. McCombe and Judith M. Greer. Microbiome and autoimmunity / Jean-Franc̦ois Bach and Alicia Perez-Arroyo. Genetic predisposition, humans / Margaret A. Jordan ... [and 3 others]. Genetic predispositin to autoimmune diseases conferred by the major histocompatibility complex : utility of animal models / Veena Taneja, Ashutosh Mangalam, and Chella S. David. Epigenetics and autoimmune diseases / Moncef Zouali. Autoimmunity in primary immunodeficiency disorders / Thomas A. Fleisher and Arnold I. Levinson -- Experimental models of autoimmunity. Animal models : systemic autoimmune diseases / Masayuki Mizui and George C. Tsokos. Animal models of organ-specific autoimmune disease / Ken Coppieters and Matthias von Herrath. Multisystem autoimmune diseases. Systemic lupus erythematosus / Robert G. Lahita. Systemic sclerosis, scleroderma / Nabeel H. Borazan and Daniel E. Furst. Antiphospholipid syndrome / Nancy Agmon-Levin, Angela Tincani, and Yehuda Shoenfeld. Sjögren’s syndrome / Clio P. Mavragani, George E. Fragoulis, and Haralampos M. Moutsopoulos. Rheumatoid arthritis / Josef S. Smolen and Kurt Redlich. Juvenile idiopathic arthritis / Clara Malattia and Alberto Martini. Spondyloarthritides / Uta Syrbe and Joachim Sieper. The autoimmune myopathies / Livia Casciola-Rosen and Antony Rosen --
Endocrine system. Thyroid disease / Anthony P. Weetman. Autoimmune (type 1) diabetes / Ahmed J. Delli and Åke Lernmark. Adrenalitis / Corrado Betterle and Renato Zanchetta. Polyendocrine syndromes / Pärt Peterson and Eystein S. Husebye. Autoimmune hypophysitis / Patrizio Caturegli, Isabella Lupi, and Angelika Gutenberg --- Blood disorders. Autoimmune hemolytic anemia / Mark A. Vickers and Robert N. Barker. Immune thrombocytopenia / Berengere Gruson and James B. Bussel. Autoimmune neutropenia / Parviz Lalezari. Acquired aplastic anemia / Robert A. Brodsky and Richard J. Jones. Monogenic autoimmune lymphoproliferative syndromes / Joao Bosco Oliveira ... [and 3 others]. Autoimmune clotting dysfunction / Christoph Königs -- Central and peripheral nervous system. Multiple sclerosis / Amanda L. Hernandez, Kevin C. O’Connor, and David A. Hafler. Peripheral neuropathies / Michael P.T. Lunn and Kazim A. Sheikh. Myasthenia gravis and related disorders / Stuart Viegas and Angela Vincent. Ocular disease / Monica D. Dalal, H. Nida Sen, and Robert B. Nussenblatt. Immune-mediated inner ear disease / Claudio Lunardi and Antonio Puccetti. Encephalomyelopathies / Eric Lancaster. Paraneoplastic neurologic syndromes / Paula K. Rauschkolb and Jerome B. Posner --- Gastrointestinal system. Celiac disease / Ludvig M. Sollid and Knut E.A. Lundin. Inflammatory bowel diseases / Vera Kandror Denmark and Lloyd Mayer. Hepatitis / Diego Vergani, Ian R. Mackay, and Giorgina Mieli-Vergani. Primary biliary cirrhosis / Carlo Selmi, Ian R. Mackay, and M. Eric Gershwin. Primary sclerosing cholangitis / John E. Eaton, Jayant A. Talwalkar, and Keith D. Lindor. Autoimmune pancreatitis and IgG4-related disease / Shigeyuki Kawa, Hideaki Hamano, and Kendo Kiyosawa --