LIST of abbreviations x // Foreword xi // 1 Introduction to tumours of the digestive system 13 // General introduction 14 // Classification of neuroendocrine neoplasms of the digestive system 16 // TNM staging of well-differentiated neuroendocrine tumours of the gastrointestinal tract 20 // 2 Tumours of the oesophagus 23 // WHO classification of tumours of the oesophagus 24 // TNM staging of tumours of the oesophagus 25 // Introduction 28 // Benign epithelial tumours and precursors // Squamous papilloma 30 // Barrett dysplasia 32 // Squamous dysplasia 36 // Malignant epithelial tumours // Adenocarcinoma of the oesophagus and oesophagogastric junction NOS 38 // Adenoid cystic carcinoma 44 // Adenosquamous and mucoepidermoid carcinomas 46 // Squamous cell carcinoma NOS 48 // Undifferentiated carcinoma 54 // Neuroendocrine neoplasms 56 // 3 Tumours of the stomach 59 // WHO classification of tumours of the stomach 60 // TNM staging of carcinomas of the stomach 61 // Introduction 64 // Gastritis and metaplasia: precursors of gastric neoplasms 65 // Benign epithelial tumours and precursors // Fundic gland polyps 67 // Hyperplastic polyps 69 // Dysplasia 71 // Intestinal-type adenoma 76 // Foveolar-type adenoma 79 // Pyloric gland adenoma 81 // Oxyntic gland adenoma 83 // Malignant epithelial tumours // Adenocarcinoma 85 // Squamous cell carcinoma 96 // Adenosquamous carcinoma 98 // Undifferentiated carcinoma 100 // Gastroblastoma 102 // Neuroendocrine neoplasms 104 // Tumours of the small intestine and ampulla 111 // WHO classification of tumours of the small intestine and ampulla 112 // TNM staging of carcinomas of the small intestine 113 // TNM staging of carcinomas of the ampulla of Vater 114 // Introduction 116 // Benign epithelial tumours and precursors // Non-ampullary adenoma 118 // Ampullary adenoma 121 // Malignant epithelial tumours // Non-ampullary adenocarcinoma 124 //
Ampullary adenocarcinoma 127 // Neuroendocrine neoplasms 131 // 5 Tumours of the appendix 135 // WHO classification of tumours of the appendix 136 // TNM staging of adenocarcinomas of the appendix 137 // Introduction 140 // Epithelial tumours // Serrated lesions and polyps 141 // Mucinous neoplasm 144 // Adenocarcinoma 147 // Goblet cell adenocarcinoma 149 // Neuroendocrine neoplasms 152 // 6 Tumours of the colon and rectum 157 // WHO classification of tumours of the colon and rectum 158 // TNM staging of carcinomas of the colon and rectum 159 // Introduction 162 // Benign epithelial tumours and precursors // Serrated lesions and polyps 163 // Conventional adenoma 170 // Inflammatory bowel disease-associated dysplasia 174 // Malignant epithelial tumours // Adenocarcinoma 177 // Neuroendocrine neoplasms 188 // 7 Tumours of the anal canal 193 // WHO classification of tumours of the anal canal 194 // TNM staging of tumours of the anal canal and perianal skin 195 Introduction 196 // Benign epithelial tumours and precursors // Inflammatory cloacogenic polyp 198 // Condyloma 200 // Squamous dysplasia (intraepithelial neoplasia) 202 // Malignant epithelial tumours // Squamous cell carcinoma 205 // Adenocarcinoma 208 // Neuroendocrine neoplasms 212 // 8 Tumours of the liver and intrahepatic bile ducts 215 // WHO classification of tumours of the liver and intrahepatic bile ducts 216 // TNM staging of tumours of the liver 217 // TNM staging of tumours of the intrahepatic bile ducts 218 // Introduction 220 // Benign hepatocellular tumours // Focal nodular hyperplasia of the liver 221 // Hepatocellular adenoma 224 // Malignant hepatocellular tumours and precursors // Hepatocellular carcinoma 229 // Hepatoblastoma 240 // Benign biliary tumours and precursors // Bile duct adenoma 245 // Biliary adenofibroma 248 // Mucinous cystic neoplasm of the liver and biliary system 250 // Biliary intraepithelial neoplasia (see Ch. 9) //
Intraductal papillary neoplasm of the bile ducts (see Ch. 9) // Malignant biliary tumours // Intrahepatic cholangiocarcinoma 254 // Combined hepatocellular-cholangiocarcinoma and undifferentiated primary liver carcinoma 260 // Hepatic neuroendocrine neoplasms 263 // 9 Tumours of the gallbladder and extrahepatic bile ducts 265 // WHO classification of tumours of the gallbladder and extrahepatic bile ducts 266 // TNM staging of tumours of the gallbladder 267 // TNM staging of tumours of the perihilar bile ducts 268 // TNM staging of tumours of the distal extrahepatic bile duct 269 // Introduction 270 // Benign epithelial tumours and precursors // Pyloric gland adenoma of the gallbladder 271 // Biliary intraepithelial neoplasia 273 // Intracholecystic papillary neoplasm 276 // Intraductal papillary neoplasm of the bile ducts 279 // Mucinous cystic neoplasm of the liver and biliary system (see Ch. 8) // Malignant epithelial tumours // Carcinoma of the gallbladder 283 // Carcinoma of the extrahepatic bile ducts 289 // Neuroendocrine neoplasms of the gallbladder and bile ducts 292 // 10 Tumours of the pancreas 295 // WHO classification of tumours of the pancreas 296 // TNM staging of carcinomas of the pancreas 297 // Introduction 298 // Benign epithelial tumours and precursors // Acinar cystic transformation 300 // Serous neoplasms 303 // Intraepithelial neoplasia 307 // Intraductal papillary mucinous neoplasm 310 // Intraductal oncocytic papillary neoplasm 315 // Intraductal tubulopapillary neoplasm 317 // Mucinous cystic neoplasm 319 // Malignant epithelial tumours // Ductal adenocarcinoma 322 // Acinar cell carcinoma 333 // Pancreatoblastoma 337 // Solid pseudopapillary neoplasm 340 // Neuroendocrine neoplasms // Introduction 343 // Non-functioning pancreatic neuroendocrine tumours 347 // Functioning neuroendocrine tumours // Insulinoma 353 // Gastrinoma 355 // VIPoma 357 // Glucagonoma 359 //
Somatostatinoma 361 // ACTH-producing neuroendocrine tumour 363 // Serotonin-producing neuroendocrine tumour 365 // Neuroendocrine carcinoma 367 // MiNENs 370 // 11 Haematolymphoid tumours of the digestive system 373 // WHO classification of haematolymphoid tumours of the digestive system 374 // Introduction 376 // Site-specific haematolymphoid tumours // Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) 378 // Duodenal-type follicular lymphoma 383 // Enteropathy-associated T-cell lymphoma 386 // Monomorphic epitheliotropic intestinal T-cell lymphoma 390 Intestinal T-cell lymphoma NOS 393 // Indolent T-cell lymphoproliferative disorder of the Gl tract 395 Hepatosplenic T-cell lymphoma 397 // EBV+ inflammatory follicular dendritic cell sarcoma 399 // Haematolymphoid tumours occurring with some frequency in the digestive system // Diffuse large B-cell lymphoma 402 // Follicular lymphoma 406 // Mantle cell lymphoma 408 // Burkitt lymphoma 411 // Plasmablastic lymphoma 415 // Posttransplant lymphoproliferative disorders 417 // Extranodal NK/T-cell lymphoma 420 // Systemic mastocytosis 423 // Langerhans cell histiocytosis 426 // Follicular dendritic cell sarcoma 428 // Histiocytic sarcoma 430 // 12 Mesenchymal tumours of the digestive system 433 // WHO classification of mesenchymal tumours of the digestive system 434 // TNM staging of gastrointestinal stromal tumours 435 // Introduction 436 // Gastrointestinal stromal tumour 439 // Adipose tissue and (myo)fibroblastic tumours // Inflammatory myofibroblastic tumour 444 // Desmoid fibromatosis 446 // Solitary fibrous tumour 448 // Lipoma 450 // Inflammatory fibroid polyp 452 // Plexiform fibromyxoma 454 // Smooth muscle and skeletal muscle tumours // Leiomyoma 456 // Leiomyosarcoma 458 // Rhabdomyosarcoma 460 // Vascular and perivascular tumours // Haemangioma 462 // Epithelioid haemangioendothelioma 466 // Kaposi sarcoma 468 // Angiosarcoma 471 // Glomus tumour 473 //
Lymphangioma and lymphangiomatosis 475 // Neural tumours // Schwannoma 477 // Granular cell tumour 479 // Perineurioma 481 // Ganglioneuroma and ganglioneuromatosis 483 // Tumours of uncertain differentiation // PEComa, including angiomyolipoma 485 // Mesenchymal hamartoma of the liver 488 // Calcifying nested stromal-epithelial tumour of the liver 490 // Synovial sarcoma 492 // Gastrointestinal clear cell sarcoma / malignant gastrointestinal neuroectodermal tumour 494 // Embryonal sarcoma of the liver 497 // 13 Other tumours of the digestive system 499 // WHO classification of other tumours of the digestive system 500 // Mucosal melanoma 502 // Germ cell tumours 504 // Metastases 506 // 14 Generic tumour syndromes of the digestive system 511 // Introduction 512 // Lynch syndrome 515 // FamiliaI adenomatous polyposis 1 522 // GAPPS and other fundic gland polyposes 526 // Other adenomatous polyposes 529 // Serrated polyposis 532 // Hereditary diffuse gastric cancer 535 // Familial pancreatic cancer 539 // Juvenile polyposis syndrome 542 // Peutz-Jeghers syndrome 545 // Cowden syndrome 547 // Other genetic tumour syndromes 550 // Contributors 551 // Declaration of interests 557 // IARC/WHO Committee for ICD-O 558 // Sources 559 // References 567 // Subject index 625 // Previous volumes in the series 635