SECTION I Basics of Laboratory Medicine, 1 // 1 Clinical Chemistry and Molecular Diagnostics, 2 - Nader Rifai, Andrea Rita Horvath, and Carl T. Wittwer // 2 Statistical Methodologies in Laboratory Medicine: Analytical and Clinical Evaluation of Laboratory Tests, 10 - Kristian Linnet, Karel G.M. Moons, and James C. Boyd // 3 Quality Management in the Medical Laboratory, 61 - David Burnett, Leslie Burnett, and Mark Mackay // 4 Specimen Collection and Processing, 62 - Doris M. Haverstick and Patricia M. Jones // 5 Preanalytical Variation and Preexamination Processes, 81 - Ana-Maria Simundic, Nora Nikolac, and Walter G. Guder // 5 Quality Control of the Analytical Examination Process, 121 - W. Greg Miller and Sverre Sandberg // 7 Biological Variation, 157 - Callum G. Fraser and Sverre Sandberg // 8 Establishment and Use of Reference Intervals, 170 - Gary Horowitz and Graham R.D. Jones // 9 Evidence-Based Laboratory Medicine, 195 - Patrick M.M. Bossuyt, Paul Glasziou, and Andrea Rita Horvath // 10 Biobanking, 196 - Christina Ellervik and Jim Vaught // 11 Laboratory Support of Pharmaceutical, In Vitro diagnostics, and Epidemiologic Studies, 197 - Mark J. Sarno, Amar A. Sethi, Omar Laterza, and Nader Rifai // SECTION II Analytical Techniques and Applications, 198 // 11 Principles of Basic Techniques and Laboratory Safety, 199 - Stanley F. Lo // 13 Optical techniques, 200 - Larry J. Kricka and Jason Y. Park // 14 Petrochemistry and Chemical Sensors, 224 - Paul D’Orazio // 15 Electrophoresis, 250 - Lindsay A.L. Bazydlo and James P. Landers // 16 Chromatography, 266 - David S. Hage // 17 Mass Spectrometry, 295 - Alan L. Rockwood, Mark M. Kushnir, and Nigel J. Clarke // 18 Sample Preparation for Mass Spectrometry Applications, 324 -David A. Wells // 19 Mass Spectrometry Applications in Infectious Disease and Pathogens Identification, 325 - Philip Heaton and Robin Patel //
20 Development and Validation of Small Molecule Analytes by Liquid Chromatography - Tandem Mass Saertrometry, 326 - Rusell P. Grant, and Brian A. Rappold // 21 Proteomics, 327 - Andrew N. Hoof nagle and Cory Bystrom // 22 Enzyme and Rate Analysis, 328 // Renze Bais and Mauro Panteghini // 23 Immunochemical Techniques, 348 // Larry J. Kricka and Jason Y. Park // 24 Microfabrication and Microfluidics and Their Application in Clinical Diagnostics, 368 - Lindsay Al. Bazydlo and James P. Landers // 25 Cytometry, 369 // Howard M. Shapiro // 26 Automation in the Clinical Laboratory, 370 - Charles D. Hawker, Jonathan R. Genzen, and Carl T. Wittwer // 27 Point-of-Care Testing, 371 - Andrew St John and Christopher P. Price // SECTION III Analytes, 372 // 28 Amino Acids, Peptides, and Proteins, 373 - Dennis J. Dietzen // 29 Serum Enzymes, 404 - Mauro Panteghini and Renze Bais // 30 Enzymes of the Red Blood Cell, 435 - Wouter W. van Solinge and Richard van Wijk // 31 Tumor Markers, 436 - Catharine Sturgeon // 32 Kidney Function Tests, 479 - Edmund J. Lamb and Graham R.D. Jones // 33 Carbohydrates, 518 - David B. Sacks // 34 Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors, 539 - Alan T. Remaley, Thomas D. Dayspring, and G. Russell Warnick // 35 Electrolytes and Blood Gases, 604 - Emily I. Schindler, Sarah M. Brown, and Mitchell G. Scott // 36 Hormones, 626 - Timothy J. Cole // 37 Vitamins and Trace Elements, 639 - Norman B. Roberts, Andrew Taylor, and Ravinder Sodi // 38 Hemoglobin, Iron, Bilirubin, 719 - M. Domenica Cappellini, Stanley F. Lo, and Dorine W. Swinkels // 39 Porphyrins and the Porphyrias, 776 - Michael N. Badminton, Sharon D. Whatley, Eliane Sardh, and Aasne K. Aarsand // 40 Therapeutic Drugs and Their Management, 800 - Michael C. Milone and Leslie M. Shaw //
41 Clinical Toxicology, 832 - Loralie J. Langman, Laura K. Bechtel, Brenton M. Meier, and Chris Holstege // 42 Toxic Elements, 888 - Frederick G. Strathmann and Lee M. Blum // 43 Body Fluids, 925 - Darci R. Block and Christopher M. Florkowski // SECTION IV Molecular Diagnostics, 926 // 44 Principles of Molecular Biology, 927 - John Greg Howe // 45 Genomes and Variants, 942 - Carl T. Wittwer and Jason Y. Park // 46 Nucleic Acid Isolation, 958 - Stephanie A. Thatcher // 47 Nucleic Acid Techniques, 959 - Carl T. Wittwer and G. Mike Makrigiorgos // 48 Molecular Microbiology, 995 - Frederick S. Nolte // 49 Genetics, 1025 - Cindy L Vnencak-Jones and D. Hunter Best // 50 Solid Tumor Genomics, 1072 - Elaine R. Mardis // 51 Genetic Aspects of Hematopoietic Malignancies, 1082 - Todd W. Kelley and Jay L Patel // 52 Circulating Tumor Cells and Circulating Tumor DNA, 1111 - Evi Lianidou and Dave Hoon // 53 Circulating Nucleic Acids for Prenatal Diagnostics, 1145 - Rossa W.K. Chiu and Y.M. Dennis Lo // 54 Pharmacogenetics, 1156 - Gwendolyn A. McMillin, Mia Wade li us, and Victoria M. Pratt // 55 Identity Testing, 1157 - Victor W. Weedn, Katherine B. Gettings, and Daniele S. Podini // SECTION V Pathophysiology, 1158 // 56 Nutrition: Laboratory and Clinical Aspects, 1159 - William J. Marshall and Ruth M. Ayling // 57 Diabetes Mellitus, 1160 - David ?. Sacks // 58 Cardiac Function, 1201 - Fred S. Apple, Jens Peter Goetze, and Allan S. Jaffe // 59 Kidney Disease, 1256 - Michael P Delaney and Edmund J. Lamb // 60 Disorders of Water, Electrolytes, and Acid-Base Metabolism, 1324 - Steven Cheng, Emily I. Schindler, and Mitchell G. Scott // 61 Liver Disease, 1348 - William Rosenberg, Tony Badrick, and Sudeep Tanwar // 62 Gastric, Pancreatic, and Intestinal Function, 1398 - Roy A. Sherwood, Natalie E. Walsham, and Ingvar Bjarnason // 63 Monoamine-Producing Tumors, 1421 - Graeme Eisenhofer, Stefan Grebe, and Nai-Kong V. Cheung //
64 Bone and Mineral Metabolism, 1422 - William D. Fraser // 65 Pituitary Function and Pathophysiology, 1492 - William E Winter, Ann McCormack, and Roger L. Bertholf // 66 Adrenal Cortex, 1530 - Roger L. Bertholf, Mark Cooper, and William E Winter // 67 Thyroid Disorders, 1572 - Danielle B. Freedman, David Halsall, William J. Marshall, and Christina Ellervik // 68 Reproductive Endocrinology and Related Disorders, 1617 - Robert D. Nerenz, Emily Jungheim, and Ann M. Gronowski // 69 Pregnancy and Its Disorders, 1655 - Melanie L Yarbrough, Molly Stout, and Ann M. Gronowski // 70 Newborn Screening and Inborn Errors of Metabolism, 1697 - Marzia Pasquali and Nicola Longo // SECTION VI Hematology and Coagulation, 1731 // 71 Hemostasis, 1732 - Russell A. Higgins, Steve Kitchen, and Dong Chen // 72 Red Blood Cell Morphology and Indices With Clinical Chemistry Interface, 1733 - Hooman H. Rachidi and Ralph Green // 73 Automated Hematology, 1734 - Devon Chabot-Richards, Qian-Yun Zhang, and Tracy I. George // SECTION VII Microbiology, 1735 // 74 Bacteriology, 1736 - Christopher D. Doern and Betty A. Forbes // 75 Antimicrobial Susceptibility Testing, 1737 - Romney M. Humphries and April N. Abbott // 76 Mycobacteriology, 1738 - Adam J. Caulfield, Rachael M. Liesman, Derrick J. Chen, and Nancy L. Wengenack // 77 Mycology, 1739 - Ingibjörg Hilmarsdóttir, Audrey N. Schuetz, and Anna F Lau // 78 Parasitology, 1740 - Esther Babady and Bobbi S. Pritt // 79 Virology, 1741 - Blake W. Buchan and Neil W. Anderson // SECTION VIII Transfusion Medicine, 1742 // 80 Blood Groups, Pretransfusion Testing, and Red Blood Cell Transfusion, 1743 - Karen Quillen // 81 Blood Components, Blood Donor Screening, and Transfusion Reactions, 1744 - John P Manis // Appendix Reference Information for the Clinical Laboratory, 1745 // Khosrow Adeli, Ferruccio Ceri otti, and Michelle Nieuwesteeg // Index, 1819