Chapter 1 cells, genomes, and the diversity of life // The universal features of life on earth 2 // Genome diversification and the tree of life 10 // Eukaryotes and the origin of the eukaryotic cell 22 // Model organisms 32 // Chapter 2 cell chemistry and bioenergetics // The chemical components of a cell 49 // Catalysis and the use of energy by cells 57 // How cells obtain energy from food 80 // Chapter 3 proteins // The atomic structure of proteins 115 // Protein function 140 // Chapter 4 DNA, chromosomes, and genomes 183 // The structure and function of DNA 185 // Chromosomal DNA and its packaging in the chromatin fiber 189 // The effect of chromatin structure on DNA function 203 // The global structure of chromosomes 217 // How genomes evolve 229 // Chapter 5 DNA replication, repair, and recombination // The maintenance of DNA sequences 253 // DNA replication mechanisms 255 // The initiation and completion of DNA replication in chromosomes 272 // DNA repair 284 // Homologous recombination 296 // Transposition and conservative site-specific recombination 306 // Chapter 6 how cells read the genome: from DNA to protein // From DNA to RNA 323 // From RNA to protein 358 // The RNA world and the origins of life 389 // Chapter 7 control of gene expression 397 // An overview of gene control 397 // Control of transcription by sequence-specific DNA-binding proteins 402 // Transcription regulators switch genes on and off 410 // Molecular genetic mechanisms that create and maintain specialized cell types 423 // Mechanisms that reinforce cell memory in plants and animals 435 // Post-transcriptional controls 445 // Regulation of gene expression by noncoding RNAs 462 // Chapter 8 analyzing cells, molecules, and systems 475 // Isolating cells and growing them in culture 476 // Purifying proteins 480 // Analyzing proteins 487 // Analyzing and manipulating DNA 498 // Studying gene function and expression 518 // Mathematical analysis of cell function 542 //
Chapter 9 visualizing cells and their molecules 563 // Looking at cells and molecules in the light microscope 563 // Looking at cells and molecules in the electron microscope 588 // Chapter 10 membrane structure // The lipid bilayer 604 // Membrane proteins 615 // Chapter 11 small-molecule transport and electrical properties of membranes // Principles of membrane transport 637 // Transporters and active membrane transport 640 // Looking at cells and molecules in the electron microscope 588 // Chapter 10 Membrane Structure // The lipid bilayer 604 // Membrane proteins 615 // Principles of membrane transport 637 // Channels and the electrical properties of membranes 651 // Chapter 12 Intracellular Organization and Protein Sorting // The compartmentalization of cells 683 // The endoplasmic reticulum 698 // Peroxisomes 723 // The transport of proteins into mitochondria and chloroplasts 726 // The transport of molecules between the nucleus and the cytosol 735 // Chapter 13 Intracellular Membrane Traffic 749 // Mechanisms of membrane transport and compartment identity 751 // Transport from the endoplasmic reticulum through the Golgi apparatus 765 // Transport from the trans golgi network to the cell exterior and endosomes 776 // Transport into the cell from the plasma membrane: endocytosis 788 // The degradation and recycling of macromolecules in lysosomes 798 // Chapter 14 Energy Conversion and Metabolic Compartmentation: Mitochondria and Chloroplasts 811 // The mitochondrion 813 // The proton pumps of the electron-transport chain 823 // ATP production in mitochondria 835 // Chloroplasts and photosynthesis 843 // The genetic systems of mitochondria and chloroplasts 861 // Chapter 15 Cell Signaling // Principles of cell signaling 873 // Signaling through G-protein-coupled receptors 892 // Signaling through enzyme-coupled receptors 911 // AlteRNAtive signaling routes in gene regulation 928 //
Signaling in plants 940 // Chapter 16 The Cytoskeleton // Function and dynamics of the cytoskeleton 949 // Myosin and actin 976 // Microtubules 987 // Intermediate filaments and other cytoskeletal polymers 1007 // Cell polarity and coordination of the cytoskeleton 1016 // Chapter 17 The Cell Cycle // Overview of the cell cycle 1027 // The cell-cycle control system 1031 // S phase 1042 // Mitosis 1046 // Cytokinesis 1064 // Meiosis 1071 // Control of cell division and cell growth 1077 // Chapter 18 Cell Death 1089 // Chapter 19 Cell Junctions and the Extracellular Matrix 1105 // Cell-cell junctions 1108 // The extracellular matrix of animals 1127 // Cell-matrix junctions 1147 // The plant cell wall 1154 // Chapter 20 Cancer // Cancer as a microevolutionary process 1163 // Cancer-critical genes: how they are found and what they do 1178 // Cancer prevention and treatment: present and future 1198 // Chapter 21 Development of Multicellular Organisms 1217 // Overview of development 1218 // Mechanisms of pattern formation 1226 // Developmental timing 1248 // Morphogenesis 1257 // Growth 1296 // Chapter 22 Stem Cells in Tissue Homeostasis and Regeneration // Stem cells and tissue homeostasis 1279 // Control of stem-cell fate and self-renewal 1291 // Regeneration and repair 1296 // Cell reprogramming and pluripotent stem cells 1300 // Chapter 23 Pathogens and Infection // Introduction to pathogens 1313 // Cell biology of pathogen infection 1325 // The human microbiota 1347 // Chapter 24 The Innate and Adaptive Immune Systems 1353 // The innate immune system 1354 // Overview of the adaptive immune system 1364 // B cells and immunoglobulins 1372 // T cells and MHC proteins 1382 // Glossary // Index