.

0 (hodnocen0 x )

EB

ONLINE

2nd ed.

Chichester, England ; Hoboken, NJ : John Wiley & Sons, c2007

1 online resource (xix, 498 p.) : ill

ISBN 0470018771 (cloth : alk. paper)

ISBN 9780470018774 (cloth : alk. paper)

Statistics in practice

Includes bibliographical references and index

Meta-analysis -- Cross-over trials -- n-of-1 trials -- Sequential trials -- Dose-finding -- Concerning pharmacokinetics and pharmacodynamics -- Bioequivalence studies -- Safety data, harms, drug monitoring, and pharmaco-epidemiology -- Pharmaco-economics and portfolio management -- Concerning pharmacogenetics, pharmacogenomics, and related matters.

A brief and superficial history of statistics for drug developers -- Design and interpretation of clinical trials as seen by a statistician -- Probability, Bayes, P-values, tests of hypotheses, and confidence intervals -- The work of the pharmaceutical statistician -- Allocating treatments to patients in clinical trials -- Baselines and covariate information --

The measurement of treatment effects -- Demographic subgroups : representation and analysis -- Multiplicity -- Intention to treat, missing data and related matters -- One-sided and two-sided tests and other issues to do with significance and P-values -- Determining the sample size -- Multicentre trials -- Active control equivalence studies --

Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries

001699607

full

(Au-PeEL)EBL351458

(CaONFJC)MIL130834

(CaPaEBR)ebr10232744

(MiAaPQ)EBC351458

(OCoLC)476172339