.

0 (hodnocen0 x )

EB

ONLINE

Hoboken, N.J. : John Wiley & Sons, c2009

1 online resource (xxviii, 470 p.) : ill

ISBN 0470229640 (cloth)

ISBN 9780470229644 (cloth)

Includes bibliographical references (p. 397-455) and index

The importance of cardiac safety assessments -- The biological basis of adverse drug reactions -- Cardiac structure and function -- Cardiac pathophysiology and disease -- Drug discovery and drug design -- Nonclinical development -- The thorough QT/QTc trial -- General safety assessments -- Therapeutic use trials and meta-analyses -- Assessment methodologies in nonexperimental postmarketing surveillance -- Postmarketing proarrhythmic cardiac safety assessments -- Generalized cardiac safety -- Medication errors, adherence, and concordance -- Future directions in drug safety.

Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries

001701124

full

(Au-PeEL)EBL406462

(CaONFJC)MIL200206

(CaPaEBR)ebr10275622

(MiAaPQ)EBC406462

(OCoLC)476225648