.

0 (hodnocen0 x )

EB

ONLINE

Hoboken, N.J. : Wiley, c2011

1 online resource (xii, 302 p.) : ill

ISBN 9781118084397 (electronic bk.)

ISBN 9781118084403 (electronic bk.)

ISBN 9780470414118 (cloth)

ISBN 9781118084410 (oIBSN)

Includes bibliographical references and index

Kinetics of single-substrate enzymatic reactions -- Kinetics of single-substrate enzymatic reactions : special topics -- Enzyme inhibition : the phenomenon and mechanistic analysis -- Kinetic mechanism of inhibition of one-substrate enzymatic reactions -- Tight-binding, slow-binding, and irreversible inhibitors -- Kinetics of two-substrate enzymatic reactions -- Kinetic mechanism of inhibition of two-substrate enzymatic reactions -- Allosteric modulation of enzyme-catalyzed reactions -- Kinetics-based probes of enzyme mechanisms.

"Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the pharmaceutical industry has in this field. Beginning with the most basic principles pertaining to simple, one-substrate enzyme reactions and their inhibitors, and progressing to a thorough treatment of two-substrate enzymes, Kinetics of Enzyme Action: Essential Principles for Drug Hunters provides biochemists, medicinal chemists, and pharmaceutical scientists with numerous case study examples to outline the tools and techniques necessary to perform, understand, and interpret detailed kinetic studies for drug discovery"--Provided by publisher..

Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries

001728387

full

(Au-PeEL)EBL693195

(CaONFJC)MIL317621

(CaPaEBR)ebr10483221

(MiAaPQ)EBC693195

(OCoLC)729718072