.

0 (hodnocen0 x )

EB

ONLINE

Hoboken, N.J. : Wiley, c2012

1 online resource (xxxv, 483 p.) : ill

ISBN 9781118354315 (electronic bk.)

ISBN 9781118028681 (cloth)

ISBN 9781118188330 (cloth)

Includes bibliographical references and index

Introduction -- Theoretical framework I : solubility -- Theoretical framework II : dissolution -- Theoretical framework III : biological membrane permeation -- Theoretical framework IV : gastrointestinal transit models and integration -- Physiology of gastrointestinal tract and other administration sites in humans and animals -- Drug parameters -- Validation of mechanistic models -- Bioequivalence and biopharmaceutical classification system -- Dose and particle size dependency -- Enabling formulations -- Food effect -- Biopharmaceutical modeling for miscellaneous cases -- Intestinal transporters -- Strategy in drug discovery and development -- Epistemology of biopharmaceutical modeling and good simulation practice.

Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries

001740066

full

(Au-PeEL)EBL875932

(CaONFJC)MIL462709

(CaPaEBR)ebr10583403

(MiAaPQ)EBC875932

(OCoLC)805560505