.

0 (hodnocen0 x )

EB

EB

ONLINE

1st ed.

Totowa, NJ : Humana Press, 2025

1 online resource (210 pages)

ISBN 9781617793943 (e-kniha)

ISBN 9781617793936

Current Clinical Pathology Series

Print version: Hui, Pei Gestational Trophoblastic Disease Totowa, NJ : Humana Press,c2025 ISBN 9781617793936

This book offers a comprehensive presentation of histological diagnosis and differential diagnoses of Gestational Trophoblastic Disease (GTD). It provides in-depth reviews of the molecular genetic background of GTD, epidemiology and risk factors..

* Gestational trophoblastic disease * GTN

002001756

Intro -- Gestational Trophoblastic Disease -- Foreword -- Preface -- Contents -- Contributors -- 1: Gestational Trophoblastic Disease: General Aspects -- Historical Remarks -- Definition and Classification of GTDs -- Epidemiology and Risk Factors -- Incidence -- Risk Factors -- Maternal Age -- Previous Pregnancies -- Ethnicity -- Genetics -- Diet or Socioeconomic Factors -- Factors not Found Etiologically Associated with GTD -- Overview of Diagnosis -- Overview of Clinical Management -- Perspectives -- References -- 2: Developmental Biology of the Placenta -- Introduction -- Placenta Formation -- Stages of Implantation -- Predecidualization and Decidualization of the Endometrium -- Phases of Implantation -- Stage 1: Apposition -- Stage 2: Attachment/Adhesion -- Stage 3: Invasion -- Placental Trophoblastic Cells -- Genomic Imprinting and Placental Development -- Imprinted X Chromosome Inactivation and Placental Development -- Co-evolution of Genomic Imprinting and Imprinted X Chromosome Inactivation -- "Parental Conflict of Interest" Theory of Genomic Imprinting -- References -- 3: Genetic Basis of Gestational Trophoblastic Disease -- Introduction -- Androgenetic Nature of Hydatidiform Moles -- Genomic Imprinting and Hydatidiform Moles -- Genetic Basis of Gestational Trophoblastic Tumors -- Gestational Trophoblastic Tumors -- Preferential Requirement of Paternal X Chromosome in Placental Site Trophoblast Tumor -- Genomic Imprinting and Paternal X Chromosome Requirement in Trophoblastic Tumors -- Perspectives -- References -- 4: Complete Hydatidiform Mole -- Introduction -- Pathogenesis -- Clinical Presentation -- Pathology -- Gross Pathology -- Histological Pathology -- Ancillary Studies -- Differential Diagnosis -- Clinicopathological Correlations -- References -- 5: Partial Hydatidiform Mole -- Introduction -- Genetic Background.

Clinical Presentation -- Gross and Microscopic Features -- Ancillary Studies -- Differential Diagnosis -- Clinicopathological Correlations -- References -- 6: Placental Site Trophoblastic Tumor -- Introduction -- Clinical Presentation -- Pathogenesis -- Pathology -- Gross Pathology -- Histological Pathology -- Ancillary Studies -- Differential Diagnoses -- Clinicopathological Correlations -- References -- 7: Epithelioid Trophoblastic Tumor -- Introduction -- Pathogenesis and Molecular Genetic Aspects -- Models of Pathogenesis for GTD, Including ETT -- DNA Genotyping -- Y-Chromosomal Complements in ETT -- Comparative Genomic Hybridization -- Expression of the Transcription Factor p63 -- Expression of Cyclin E -- Epidermal Growth Factor Receptor (EGFR) Expression -- K-Ras Oncogene -- ETT of the Lung -- Clinical Presentation -- Clinical features (Table 7.1) -- Imaging Studies -- Pathology -- Macroscopic Findings (Figs.  7.1 and 7.2) -- Histologic Findings (Table  7.2 , Fig.  7.3) -- Cytological Findings -- Ancillary Studies -- Electron Microscopy -- Immunohistochemistry Fig. 7.6 -- Hydroxyl- d -5-Steroid Dehydrogenase (HSD3B1) (Diagram 7.1) -- Human Leukocyte Antigen G (Diagram  7.1) -- Inhibin- a (Diagram  7.1) -- P63 (Diagram  7.2) -- Human Placental Lactogen (Diagram  7.2) -- Melanoma Cell Adhesion Molecule (Diagram  7.2) -- Other Immunohistochemical Marker -- Differential Diagnosis -- ETT vs. Squamous Cell Carcinoma Table 7.3 -- ETT vs. PSTT (Table  7.4) -- ETT vs. Choriocarcinoma -- ETT vs. PSN -- ETT vs. Epithelioid Leiomyosarcoma Table 7.3 -- Rare Differential Diagnosis of ETT -- Metastatic Disease and Extrauterine ETT, Especially Lung Lesions -- Clinicopathological Correlations -- Clinical Staging -- Clinical Management -- Prognosis and Prognostic Markers -- Future Molecular Targets -- References -- 8: Gestational Choriocarcinoma -- Introduction.

Clinical Presentation -- Pathogenesis -- Pathology -- Gross Pathology -- Histological Pathology -- In Situ or Intraplacental Choriocarcinoma -- Ancillary Studies -- Differential Diagnosis -- Complete Hydatidiform Mole -- Early Gestational Villous Trophoblast -- Exaggerated Placental Site Reaction -- Intermediate Trophoblastic Tumors (PSTT and ETT) -- Nongestational Choriocarcinoma -- Poorly Differentiated Uterine Carcinomas -- Clinicopathological Correlations -- References -- 9: Persistent Trophoblastic Neoplasia -- Introduction -- Pathology -- Persistent Mole -- Invasive Mole Including Metastatic Mole -- Gestational Trophoblastic Tumors -- Prognosis -- References -- 10: Tumor-Like Trophoblastic Conditions -- Introduction -- Placental Site Nodule/Plaque -- Clinical Features -- Pathogenesis -- Pathology -- Ancillary Studies -- Differential Diagnosis -- Clinicopathological Correlations -- Exaggerated Placental Site Reaction -- Clinical Features -- Pathogenesis -- Pathology -- Ancillary Studies -- Differential Diagnosis -- Clinicopathological Correlations -- References -- 11: Molecular Diagnosis of Gestational Trophoblastic Disease -- Introduction -- Genetic Basis of Molecular Diagnosis -- Methods of Molecular Diagnosis -- STR Genotyping Diagnosis of Hydatidiform Moles -- Interpretation of STR PCR data -- Target Tissue Selection and Processing -- Diagnostic Pitfalls of STR Genotyping -- STR Genotyping Diagnosis of Gestational Trophoblastic Tumors -- Prospective -- Conclusions -- References -- 12: Clinical Aspects of Gestational Trophoblastic Disease -- Introduction -- Diagnosis -- Hydatidiform Mole -- Epidemiology Hydatidiform Moles -- Partial vs. Complete Hydatidiform Moles -- Clinical Presentation and Diagnosis of Hydatidiform Moles -- Treatment of Hydatidiform Moles -- Follow-Up After Hydatidiform Moles -- Gestational Trophoblastic Neoplasia.

Diagnosis of GTN -- Staging of GTN -- Clinical Presentation GTN -- Choriocarcinoma -- PSTT -- ETT -- Treatment of GTN -- Treatment of Low-Risk Disease -- Treatment of High-Risk Metastatic Disease -- Treatment of PSTT and ETT -- Treatment Failure GTN -- Follow-Up GTN -- References -- Appendix -- Index.

(MiAaPQ)EBC884433

(Au-PeEL)EBL884433

(CaPaEBR)ebr10520947

(CaONFJC)MIL344771

(OCoLC)779197716