.

0 (hodnocen0 x )

EB

ONLINE

New York : Nova Science Publishers, [2020]

1 online resource (184 pages)

ISBN 9781536166798 (e-book)

ISBN 9781536166781

Biochemistry research trends

Print version: Micronucleus assay : an overview. New York : Nova Science Publishers, c2020 184 pages Biochemistry research trends series. ISBN 9781536166781

Obsahuje bibliografii a rejstřík

In the concluding review, generation of micronucleus assay in the bone marrow cells of mice induced by various clastogenic chemicals, drugs, and radiation are elaborately elucidated. Bone marrow cells are easily susceptible to oxidative damage and sensitive to various clastogenic as well as aneugenic agents"--..

Micronucleus is defined as the small nucleus that forms whenever a chromosome or its fragment is not incorporated into one of the daughter nuclei during cell division. It is concluded that micronucleus assay can be used for risk prediction, screening, diagnosis and treatment of various chronic diseases. In this Micronucleus Assay: An Overview, the applications of micronucleus assay will be discussed. Ionizating radiations, ultraviolet rays, geogenic or anthropogenic pollutants can induce mutagenic, teratogenic or carcinogenic effects due to the induction of micro or macrolession over DNA. Several models have been used to measure the mutagenic and clastogenic effect of such agents. As such, the authors focus on one of these models: the micronucleus test. The micronucleus test can assess abnormalities earlier in the drug discovery pipeline, making structure/genotoxicity connection a possible system for drug characterization.-.

002007252

full

(Au-PeEL)EBL6028635

(MiAaPQ)EBC6028635

(OCoLC)1138673300