Brief Contents // PART 1 THE MOLECULAR DESIGN OF LIFE // Prelude 3 // Biochemical Evolution 19 // 3 Protein Structure and Function 41 // Exploring Proteins 77 // RIMA, DNA, and the Flow of Genetic Information 117 // Exploring Genes 143 // Exploring Evolution (including Bioinformatics 171 // Enzymes: Basic Concepts and Kinetics 189 // Catalytic Strategies 227 // Regulatory Strategies: Enzymes and Hemoglobin 261 // Carbohydrates 295 // Lipids and Cell Membranes 319 // Membrane Channels and Pumps 345 // PART II TRANSDUCING AND STORING ENERGY // Metabolism: Basic Concepts and Design 373 // 5 Signal-Transduction Pathways: An Introduction to Information Metabolism 395 // 6 Glycolysis and Gluconeogenesis 425 // The Citric Acid Cycle 465 // Oxidative Phosphorylation 491 // The Light Reactions of Photosynthesis 527 // The Calvin Cycle and the Pentose Phosphate Pathway 551 // Glycogen Metabolism 577 // Fatty Acid Metabolism 601 // Protein Turnover and Amino Acid Catabolism 633 // PART III SYNTHESIZING THE MOLECULES OF LIFE // The Biosynthesis of Amino Acids 665 // Nucleotide Biosynthesis 693 // The Biosynthesis of Membrane Lipids and Steroids 715 // DNA Replication, Recombination, and Repair 745 // RNA Synthesis and Splicing 781 // Protein Synthesis 813 // The integration of Metabolism 845 // The Control of Gene Expression 867 // PART IV RESPONDING TO --- ENVIRONMENTAL CHANGES // Sensory Systems // The Immune System // Molecular Motors