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BK

Sixth edition

New York : Garland Science, Taylor & Francis Group, [2015]

xvi, 966 stran : barevné ilustrace ; 28 cm

ISBN 978-0-8153-4453-7 (brožováno)

"Also includes complete solutions to the end-of-chapter problems ... "--Obálka

Obsahuje bibliografické odkazy a rejstřík

001470764

Contents // Problems // Chapter 1 Cells and Genomes 1 // Chapter 2 Cell Chemistry and Bioenergetics 11 // Chapter 3 Proteins 31 // Chapter 4 DNA, Chromosomes, and Genomes 53 // Chapter 5 DNA Replication, Repair, and Recombination 77 // Chapter 6 How Cells Read the Genome: From DNA to Protein 105 // Chapter 7 Control of Gene Expression 135 // Chapter 8 Analyzing Cells, Molecules, and Systems 167 // Chapter 9 Visualizing Cells 197 // Chapter 10 Membrane Structure 209 // Chapter 11 Membrane Transport of Small Molecules and the Electrical Properties of Membranes 219 // Chapter 12 Intracellular Compartments and Protein Sorting 237 // Chapter 13 Intracellular Membrane Traffic 259 // Chapter 14 Energy Conversion: Mitochondria and Chloroplasts 285 // Chapter 15 Cell Signaling 307 // Chapter 16 The Cytoskeleton 333 // Chapter 17 The Cell Cycle 361 // Chapter 18 Cell Death 387 // Chapter 19 Cell Junctions and the Extracellular Matrix 393 // Chapter 20 Cancer 415 // Answers to Problems 435 // Answers to Problems in Molecular Biology of the Cell, Sixth Edition 861 // Credits 931 // Index 935 // Tables 963 // xiv // Detailed Contents // Problems // Chapter 1 Cells and Genomes 1 // THE UNIVERSAL FEATURES OF CELLS ON EARTH 1 // THE DIVERSITY OF GENOMES AND THE TREE OF LIFE 4 GENETIC INFORMATION IN EUKARYOTES 6 // Chapter 2 Cell Chemistry and Bioenergetics 11 // THE CHEMICAL COMPONENTS OF A CELL 11 // CATALYSIS AND THE USE OF ENERGY BY CELLS 19 // HOW CELLS OBTAIN ENERGY FROM FOOD 24 // Chapter

3 Proteins 31 // THE SHAPE AND STRUCTURE OF PROTEINS 31 // PROTEIN FUNCTION 37 // Chapter 4 DNA, Chromosomes, and Genomes 53 // THE STRUCTURE AND FUNCTION OF DNA 53 // CHROMOSOMAL DNA AND ITS PACKAGING // IN THE CHROMATIN FIBER 55 // CHROMATIN STRUCTURE AND FUNCTION 59 // THE GLOBAL STRUCTURE OF CHROMOSOMES 64 // HOW GENOMES EVOLVE 67 // Chapter 5 DNA Replication, Repair, // and Recombination 77 // THE MAINTENANCE OF DNA SEQUENCES 77 // DNA REPLICATION MECHANISMS 78 // THE INITIATION AND COMPLETION OF DNA // REPLICATION IN CHROMOSOMES 84 // DNA REPAIR 90 // HOMOLOGOUS RECOMBINATION 95 // TRANSPOSITION AND CONSERVATIVE // SITE-SPECIFIC RECOMBINATION 99 // Chapter 6 How Cells Read the Genome: // From DNA to Protein 105 // FROM DNA TORNA 105 // FROM RNA TO PROTEIN 118 // THE RNA WORLD AND THE ORIGINS OF LIFE 130 // Chapter 7 Control of Gene Expression 135 // AN OVERVIEW OF GENE CONTROL 135 // CONTROL OF TRANSCRIPTION BY // SEQUENCE-SPECIFIC DNA-BINDING PROTEINS 137 // TRANSCRIPTION REGULATORS SWITCH GENES // ON AND OFF 144 // MOLECULAR GENETIC MECHANISMS THAT CREATE AND MAINTAIN SPECIALIZED CELL TYPES 149 // MECHANISMS THAT REINFORCE CELL MEMORY // IN PLANTS AND ANIMALS 154 // POST-TRANSCRIPTIONAL CONTROLS 157 // REGULATION OF GENE EXPRESSION BY // NONCODING RNAS 161 // Chapter 8 Analyzing Cells, Molecules, // and Systems 167 // ISOLATING CELLS AND GROWING THEM IN // CULTURE 167 // PURIFYING PROTEINS 168 // ANALYZING PROTEINS 172 // ANALYZING AND MANIPULATING DNA 177 // STUDYING

GENE EXPRESSION AND FUNCTION 184 // MATHEMATICAL ANALYSIS OF CELL FUNCTIONS 190 // Chapter 9 Visualizing Cells 197 // LOOKING AT CELLS IN THE LIGHT MICROSCOPE 197 // LOOKING AT CELLS AND MOLECULES IN THE // ELECTRON MICROSCOPE 204 // Zested Contents // XV // Chapter 10 Membrane Structure 209 // THE UPID BILAYER 209 // MEMBRANE PROTEINS 214 // Chapter 11 Membrane Transport of // Small Molecules and the Electrical // Properties of Membranes 219 // PRINCIPLES OF MEMBRANE TRANSPORT 219 // TRANSPORTERS AND ACTIVE MEMBRANE // TRANSPORT 222 // CHANNELS AND THE ELECTRICAL PROPERTIES // OF MEMBRANES 227 // Chapter 12 Intracellular Compartments // and Protein Sorting 237 // THE COMPARTMENTALIZATION OF CELLS 237 // THE TRANSPORT OF MOLECULES BETWEEN THE // NUCLEUS AND THE CYTOSOL 240 // THE TRANSPORT OF PROTEINS INTO // MITOCHONDRIA AND CHLOROPLASTS 246 // PEROXISOMES 249 // THE ENDOPLASMIC RETICULUM 252 // Chapter 13 Intracellular Membrane // Traffic 259 // THE MOLECULAR MECHANISMS OF MEMBRANE TRANSPORT AND THE MAINTENANCE OF COMPARTMENTAL DIVERSITY 259 // TRANSPORT FROM THE ER THROUGH THE // GOLGI APPARATUS 264 // TRANSPORT FROM THE TRANS GOLGI NETWORK // TO LYSOSOMES 269 // TRANSPORT INTO THE CELL FROM THE PLASMA // MEMBRANE: ENDOCYTOSIS 272 // TRANSPORT FROM THE TRANS GOLGI NETWORK // TO THE CELL EXTERIOR: EXOCYTOSIS 277 // Chapter 14 Energy Conversion: // Mitochondria and Chloroplasts 285 // THE MITOCHONDRION 285 // THE PROTON PUMPS OF THE ELECTRON- // TRANSPORT CHAIN 287 // ATP PRODUCTION

IN MITOCHONDRIA 292 // CHLOROPLASTS AND PHOTOSYNTHESIS 296 // THE GENETIC SYSTEMS OF MITOCHONDRIA // AND CHLOROPLASTS 301 // Chapter 15 Cell Signaling 307 // PRINCIPLES OF CELL SIGNALING 307 // SIGNALING THROUGH G-PROTEIN-COUPLED // RECEPTORS 312 // SIGNALING THROUGH ENZYME-COUPLED // RECEPTORS 320 // ALTERNATIVE SIGNALING ROUTES IN GENE // REGULATION 325 // SIGNALING IN PLANTS 329 // Chapter 16 The Cytoskeleton 333 // FUNCTION AND ORIGIN OF THE CYTOSKELETON 333 ACTIN AND ACTIN-BINDING PROTEINS 335 // MYOSIN AND ACTIN 340 // MICROTUBULES 344 // INTERMEDIATE FILAMENTS AND SEPTINS 353 // CELL POLARIZATION AND MIGRATION 356 // Chapter 17 The Cell Cycle 361 // OVERVIEW OF THE CELL CYCLE 361 // THE CELL-CYCLE CONTROL SYSTEM 364 // S PHASE 366 // MITOSIS 368 // CYTOKINESIS 376 // MEIOSIS 379 // CONTROL OF CELL DIVISION AND CELL GROWTH 380 // Chapter 18 Cell Death 387 // Chapter 19 Cell Junctions and the Extracellular Matrix 393 // CELL-CELL JUNCTIONS 393 // THE EXTRACELLULAR MATRIX OF ANIMALS 403 // CELL-MATRIX JUNCTIONS 408 // THE PLANT CELL WALL 410 // Chapter 20 Cancer 415 // CANCER AS A MICROEVOLUTIONARY PROCESS 415 // CANCER-CRITICAL GENES: HOW THEY ARE // FOUND AND WHAT THEY DO 418 // xvi // Detailed Contents // CANCER PREVENTION AND TREATMENT: // PRESENT AND FUTURE 426 // Answers to Problems 435 // Answers to Problems in Molecular Biology // of the Cell, Sixth Edition 861 // Credits 931 // Index 935 // Table 1 Constants 963 // Table 2 Variables 963 // Table 3 Units 964 // Table

4 Prefixes 965 // Table 5 Geometric Formulas 965 // Table 6 Radioactive Isotopes 965 // Table 7 The Genetic Code 966 // Table 8 Amino Acids and Codons 966