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BK

Twelfth edition

Edinburgh ; London ; New York ; Oxford ; Philadelphia ; St Louis ; Sydney : Elsevier, 2019

xiii, 706 stran : barevné ilustrace ; 24 cm

ISBN 978-0-7020-7328-1 (brožováno)

Obsahuje bibliografie, bibliografické odkazy a rejstřík

001481632

Preface ...vii // List of contributors ...ix // Acknowledgements ...xiii // Section 1: General // 1 Clinical pharmacology ...2 Mike Schächter // 2 Topics in drug therapy ...5 Mike Schächter // 3 Discovery and development of drugs ...28 Patrick Vallarne // 4 Evaluation of dmgs in humans ...37 Ian Hudson, June Raine // 5 Health technology assessment ...56 Michael Rawlins // 6 Regulation of medicines ...63 Ian Hudson, Keith MacDonald, June Raine // 7 Classification and naming of dmgs ...71 Morris J. Brown // Section 2: From pharmacology to toxicology // 8 General pharmacology ...76 Mike Schächter, Munir Pirmohamed // 9 Unwanted effects and adverse dmg reactions ...112 Mike Schächter // 10 Poisoning, overdose, antidotes ...125 Stephen Haydock // 11 Dmg dependence ...139 Stephen Haydock // Section 3: Infection and inflammation // 12 Chemotherapy of infections ...166 David A. Enoch, Mark Farrington // 13 Antibacterial dmgs ...178 David A. Enoch, Mark Farrington // 14 Chemotherapy of bacterial infections ...198 David A. Enoch, Mark Farrington, Surender K. Sharma // 15 Viral, fungal, protozoal and helminthic infections ...221 Sani Aliyu // 16 Dmgs for inflammation and joint disease ...248 Clare Thornton, Justin C. Mason // 17 Dmgs and the skin ...269 Thomas ?. ?. Ha // Section 4: Nervous system // 18 Pain and analgesics ...288 Michael C. Lee, Mark Abrahams // 19 Anaesthesia and neuromuscular block ...308 Jerry P. Nolan // 20 Psychotropic drugs ...324 David Nutt, Simon Davies, Blanca M. Bolea-Alamanac // 21 Neurological disorders - epilepsy, Parkinson’s disease and multiple sclerosis ...365 Paul Bentley, Panhaj Sharma // Section 5: Cardiorespiratory and renal systems // 22 Cholinergic and antimuscarinic (anticholinergic) mechanisms and drugs ...392 Morris J. Brown, Praz A. Mir // 23 Adrenergic mechanisms and drugs ...403 Morris J. Brown //

24 Arterial hypertension, angina pectoris, myocardial infarction and heart failure ...415 Morris J. Brown // 25 Cardiac arrhythmia ...451 Andrew Grace // 26 Hyperlipidaemias ...468 John P D. Reckless // 27 Kidney and genitourinary tract ...479 Thomas E Hiemstra // 28 Respiratory system ...495 Lucinda Kennard // Section 6: Blood and neoplastic disease // 29 Drugs and haemostasis ...512 Mike Laffan, Trevor Baglin // 30 Red blood cell disorders ...528 M. Hasib Sidiqi, Wendy N. Erber // 31 Neoplastic disease and immunosuppression ...543 Harpreet Wasan // Section 7: Gastrointestinal system // 32 Oesophagus, stomach and duodenum ...562 Devinder Singh Barisi, Charlotte Hateley, John Louis-Auguste // 33 Intestines ...570 Devinder Singh Bansi, Charlotte Hateley, John Louis-Auguste // 34 Liver and biliary tract ...581 Graeme Alexander // Section 8: Endocrine system, metabolic conditions // 35 Adrenal corticosteroids, antagonists, corticotropin ...594 Diana C. Brown, Morris J. Brown // 36 Diabetes mellitus, insulin, oral antidiabetes agents, obesity ...608 Mark Evans, Rahat Tauni // 37 Thyroid hormones, antithyroid drugs ...625 Diana C. Brown // 38 Hypothalamic, pituitary and sex hormones ...635 Karim Meeran // 39 Vitamins, calcium, bone ...655 Chrysothemis Brown // Index ...667