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0 (hodnocen0 x )

BK

Cambridge (MA); London : Harvard University Press, 2020

vi, 522 stran ; 25 cm

ISBN 978-0-674-28136-3 (vázáno)

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001640548

Contents // Introduction 1 // I PART ONE THE BIRTH OF MOLECULAR BIOLOGY // 1 The Roots of the New Science 13 // 2 The One Gene-One Enzyme Hypothesis 23 // 3 The Chemical Nature of the Gene 32 // 4 The Phage Group 41 // 5 The Birth of Bacterial Genetics 52 // 6 The Crystallization of the Tobacco Mosaic Virus 63 // 7 Enter the Physicists 67 // 8 The Influence of the Rockefeller Foundation 79 // 9 Physical Techniques in Molecular Biology 88 // 10 The Role of Physics 99 // 1 PART TWO THE DEVELOPMENT OF MOLECULAR BIOLOGY // 11 The Discovery of the Double Helix 105 // 12 Deciphering the Genetic Code 120 // 13 The Discovery of Messenger RNA 138 // 14 The French School // 148 // VI // Contents // 1 PART THREE THE EXPANSION OF MOLECULAR BIOLOGY // 15 Normal Science 165 // 16 Genetic Engineering 179 // 17 Split Genes and Splicing 200 // 18 The Discovery of Oncogenes 211 // 19 From DNA Polymerase to the Amplification of DNA PART FOUR BEYOND MOLECULAR BIOLOGY? 222 // 20 The Molecularization of Biology and Medicine 235 // 21 Protein Structure 251 // 22 The Rise of Developmental Biology 263 // 23 Molecular Biology and Evolution 278 // 24 Gene Therapy 297 // 25 The Central Place of RNA 311 // 26 Epigenetics 325 // 27 Sequencing the Human Genome 340 // 28 Systems Biology and Synthetic Biology 355 // 29 Images, Representations, and Metaphors in Molecular Biology 369 // General Conclusion 385 // 389 393 // Appendix: Definition of Terms // Notes // Index // 503