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0 (hodnocen0 x )

EB

EB

ONLINE

Champaign, IL : Human Kinetics, 2007

1 online zdroj

ISBN 9781492595540 (online)

ISBN 9781492578413 (PDF ebook)

ISBN 9780736063432 (print)

Primers in exercise science series

Obsahuje bibliografické odkazy

Genetics Primer for Exercise Science and Health is the first text dedicated to the basic concepts of genetics in relation to the broad range of topics in exercise science and health. Author Stephen M. Roth, PhD, makes the content comprehensible for readers who are unfamiliar with genetics without sacrificing the foundational and critical understanding necessary for interpreting research findings and incorporating genetics into research programs. Genetics Primer for Exercise Science and Health maintains a practical focus and addresses common concerns when preparing to study genetics, such as how to use online search tools to identify existing research literature and how to identify and select candidate genes using genome databases. Through this text, readers will discover these concepts: The basics of DNA and genetics as they relate to health, physical activity, and sport; Specific skills and strategies for interpreting and applying genetics findings in research; How genetics research may affect sport performance training and clinical practice; The ethical issues raised by genetics in society and sport. Special focus sections are incorporated throughout the text, providing expanded discussions of interesting topics in each chapter. Students see examples of how the principles described in the book have played out in real-life research, and they receive explicit instructions on planning and interpreting genetics research. Pedagogical aids such as summaries, key terms, and review questions also make this text ideal for efficient learning. Part I presents readers with the basic biology and genetics information they need in order to understand and apply the information to exercise science. (...).

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Part I. Basics of Genetics -- Chapter 1. Individual Differences: The Role of Genetics in Exercise Science and Health ; Hidden Aspect of Average Values ; Why Do We See Variation in a Physical Trait? ; Summary ; Learning Aids -- Chapter 2. DNA, RNA, and Protein ; Basic Cell Biology ; DNA ; Our Genetic Material as Chromosomes ; Special Focus: The Human Genome Project ; RNA ; Amino Acids and Proteins ; Structure of Genes ; Summary ; Learning Aids -- Chapter 3. Transcription, Translation, and the Genetic Code ; Moving From DNA to RNA: Transcription ; Posttranscriptional Modifications of RNA ; Moving From RNA to Protein: Translation ; Posttranslational Modifications of Proteins ; Genetic Code ; Summary ; Learning Aids -- Chapter 4. Moving Genetic Material to the Next Generation ; Basic Reproduction ; Sex Cell Production and Meiosis ; Special Focus: Mitosis Versus Meiosis ; Chromosomal Recombination ; Mendelian Inheritance Patterns ; Summary ; Learning Aids -- Chapter 5. Heritability and the Basics of Genetic Variation ; Familial Resemblance: Genes and Environment ; Heritability as a Measure of Genetic Contribution ; Special Focus: Twin and Family Studies ; Genetic Variation ; Types of Genetic Variation ; Special Focus: Labeling Polymorphisms ; How Genetic Variation Can Influence Physical Traits ; How Do Polymorphisms Arise? Genetic Variation and Evolution ; Summary ; Learning Aids -- Chapter 6. Genetic Variation and Disease ; Mendelian Disease Genetics ; Special Focus: Muscular Dystrophy ; Complex Disease ; Special Focus: Obesity as a Complex Trait ; Gene x Environment Interactions ; Gene x Gene Interactions ; Summary ; Learning Aids --

Chapter 7. Linkage Disequilibrium, Haplotype, and Environmental Interaction ; Recombination Revisited ; Linkage Disequilibrium ; Linkage Analysis in Families ; Haplotype: Combinations of Neighboring Alleles ; Special Focus: The International HapMap Project ; Diplotype: Combinations of Haplotypes ; Gene x Environment Interaction Revisited ; An Introduction to Epigenetics ; Summary ; Learning Aids -- Part II. Research Design and Methods -- Chapter 8. Getting Started: Basic Skills for Genetics Research ; Is Genetic Variation Important for My Trait of Interest? ; Using PubMed ; Interpreting Existing Literature ; Identifying and Selecting Candidate Genes and Polymorphisms ; Using Genome Databases ; Summary ; Learning Aids -- Chapter 9. Issues in Study Design and Analysis ; How Genetics Necessarily Alters Study Design ; Typical Study Designs ; Subject Recruitment ; Geographical Ancestry ; Special Focus: Race in Genetics ; Prospective Versus Retrospective ; Statistical Approaches ; Interpretation of Results: Association versus Cause and Effect ; Summary ; Learning Aids -- Chapter 10. Basic Laboratory Methods in Genetics ; DNA from Blood or Cheek Cells ; Polymerase Chain Reaction (PCR) ; Genotyping with Restriction Enzymes ; Genotyping with Fluorescent Tags ; Special Focus: DNA Microarrays ; DNA Sequencing ; Summary ; Learning Aids -- Part III. Current Findings and Extensions of Genetics Research --

Chapter 11. Current Research Findings in the Genetics of Exercise Science and Health ; Overview of Current Findings ; Special Focus: The Human Gene Map for Performance and Health-Related Fitness Phenotypes ; ACTN3 and Muscular Performance ; ApoE and Cognitive Impairment ; ACE and Sport Performance ; Myostatin and Muscle Mass ; Summary ; Learning Aids -- Chapter 12. Personalized Medicine ; Genetics and Complex Disease Revisited ; Promise and Limitations of Personalized Medicine ; Special Focus: Pharmacogenomics ; Genetics in Nutrition and Exercise Prescription ; Genetics in Disease Prevention ; Summary ; Learning Aids -- Chapter 13. Ethical Challenges in Genetics and Society ; Ethical, Legal, and Social Implications of Genomics Gene Therapy for Disease Treatment ; Special Focus: Stem Cells ; Genetics in Sport: Genetic Testing and Gene Doping for Performance ; Summary ; Learning Aids -- Appendix A: Answers to Review Questions -- Appendix B: Evolution and Hardy-Weinberg Equilibrium -- Glossary -- Bibliography -- Index -- About the Author