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EB

EB

ONLINE

Champaign, IL : Human Kinetics, 2008

1 online zdroj

ISBN 9781492595748 (online)

ISBN 9781492574064 (PDF ebook)

ISBN 9780736064798 (print)

Obsahuje bibliografické odkazy

Over the past 50 years, there has been a dramatic increase in the prevalence of interrelated metabolic disease states, including obesity, insulin resistance, and type 2 diabetes mellitus. In modern Western nations, the population-based prevalence of insulin resistance is approaching 20%, and type 2 diabetes is now the most common endocrine disorder in adults. No longer a disease reserved for the aging population, type 2 diabetes is also on the rise in adolescents. Approximately 30% of all newly diagnosed cases (between 1982 and 1994 in the United States alone) are among people 10 to 19 years of age. For those engaged in a struggle against this modern-day epidemic, Physical Activity and Type 2 Diabetes provides cutting-edge research to energize current efforts in diabetes prevention, management, and treatment.-.

The most in-depth and up-to-date book on the topic, Physical Activity and Type 2 Diabetes presents a series of independent but related chapters authored by the foremost researchers of insulin resistance examining topics such as these: Physical inactivity as a primary cause for the rising incidence of insulin resistance; The emergence of an "exercise-deficient" phenotype; The effects of exercise training on selected aspects of substrate metabolism; The role of endurance and resistance training programs for the prevention and treatment of insulin resistance; The identification of new molecular targets and pathways useful for the treatment of insulin resistance and type 2 diabetes. Physical Activity and Type 2 Diabetes provides a four-part, in-depth examination of the relational nature of diabetes and physical activity. Part I begins with a description of the scope and extent of the "diabesity" epidemic.-.

The risk factors for diabetes, the underlying causes of the epidemic, and its potential consequences are outlined as well as the role of physical inactivity in the pathogenesis of diabetes and plans for preventive exercise biology. Part II continues with an examination of some of the major defects of substrate metabolism in individuals with insulin resistance, while in part III the authors discuss the impact of exercise interventions in the prevention, management, and treatment of type 2 diabetes. Part IV presents recent developments in molecular and cellular biology that may provide treatment therapies for the prevention of type 2 diabetes. Based on extensive research, Physical Activity and Type 2 Diabetes presents a wealth of information to assist the biomedical and research community in creating prescriptive therapeutic tools for type 2 diabetes intervention--and offers hope for the alleviation of the global epidemic of insulin resistance.

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Part I. Aetiology of Insulin Resistance and Type 2 Diabetes: Prevalence and Consequences of the "Diabesity" Epidemic -- Chapter 1. The Increasing Burden of Type 2 Diabetes: Magnitude, Causes, and Implications of the Epidemic / Edward W. Gregg, PhD, and Andrea K. Kriska, PhD -- Chapter 2. Waging War on Type 2 Diabetes: Primary Prevention Through Exercise Biology / Frank W. Booth, Manu V. Chakravarthy, and Matthew J. Laye -- Part II. Defects in Metabolism and Insulin Resistance -- Chapter 3. Fatty Acid Uptake and Insulin Resistance / Arend Bonen, Adrian Chabowski, Jan F.C. Glatz, and Joost J.F.P. Luiken -- Chapter 4. Lipid Metabolism and Insulin Signaling / Jason R. Berggren, Leslie A. Consitt, and Joseph A. Houmard -- Chapter 5. Metabolic Inflexibility and Insulin Resistance / Bret Goodpaster, PhD, and David E. Kelley, MD -- Chapter 6. Nutrient Sensor Links Obesity With Diabetes Risk / Sarah Crunkhorn and Mary Elizabeth Patti -- Chapter 7. Inflammation-Induced Insulin Resistance in Obesity: When Immunity Affects Metabolic Control / Phillip James White and Andre ́Marette -- Part III. Prevention of Type 2 Diabetes Through Exercise Training -- Chapter 8. Transcription Factors Regulating Exercise Adaptation / David Kitz Kram̈er and Anna Krook -- Chapter 9. Exercise and Calorie Restriction Use Different Mechanisms to Improve Insulin Sensitivity / Gregory D. Cartee, PhD -- Chapter 10. Mitochondrial Oxidative Capacity and Insulin Resistance / Kevin R. Short -- Chapter 11. Effects of Acute Exercise and Exercise Training on Insulin Action in Skeletal Muscle / Erik A. Richter and Jørgen F.P. Wojtaszewski -- Chapter 12. Resistance Exercise Training and the Management of Diabetes / Jørgen F.P Wojtaszewski, Henriette Pilegaard, and Flemming Dela -- Part IV. Prevention of Type 2 Diabetes: Identification of Novel Molecular Targets and Pathways --

Chapter 13. AMPK: The Master Switch for Type 2 Diabetes? / W.W. Winder and D.M Thomson -- Chapter 14. Protein Kinase C and Insulin Resistance / Carsten Schmitz-Peiffer -- Chapter 15. Evidence for the Prescription of Exercise as a Therapy for the Treatment of Patients With Type 2 Diabetes / Sarah J. Lessard and John A. Hawley