.

0 (hodnocen0 x )

EB

ONLINE

Hoboken, N.J. : Wiley, c2011

1 online resource (xvii, 430 p.) : ill

ISBN 9781118140383 (electronic bk.)

ISBN 9780470484067 (cloth)

Includes bibliographical references and index

Modelling in the pharmaceutical industry -- Physiologically-based modelling -- A review of pharmacokinetic principles -- Physiological model for absorption -- Physiological model for distribution -- Physiological models for drug metabolism and excretion -- Generic whole-body physiologically-based pharmacokinetic modelling -- Variability, uncertainty and sensitivity analysis -- Evaluation of drug-drug interaction risk with pbpk models -- PBPK of biotherapeutics -- Data integration and sensitivity analysis -- Hypothesis generation and pharmacokinetic predictions -- Integration of PBPK and pharmacodynamics -- PBPK modelling of populations -- PBPK models along the drug discovery and development value chain.

Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries

001735634

full

(Au-PeEL)EBL818462

(CaONFJC)MIL361846

(CaPaEBR)ebr10558150

(MiAaPQ)EBC818462

(OCoLC)794619804