.

0 (hodnocen0 x )

EB

ONLINE

Hoboken, N.J. : John Wiley & Sons, Inc., 2012

1 online resource (xvi, 443 p., [12] p. of plates) : ill. (some col.)

ISBN 9781118150542 (electronic bk.)

ISBN 9780470497180 (cloth)

Includes bibliographical references

The critical need for robust assays for quantitation and characterization of aggregates of therapeutic proteins -- Separation based analytical methods for measuring protein aggregation -- Laser light scattering-based techniques used for the characterization of protein therapeutics -- Online detection methods and emerging techniques for soluble aggregates in protein pharmaceuticals -- Analytical methods to measure sub-visible particulates -- Detection of visible particles in parenteral products -- Characterization of aggregates and particles using emerging techniques -- Ultraviolet absorption spectroscopy -- Fluorescence spectroscopy to characterize protein aggregates and particles -- Infrared spectroscopy to characterize protein aggregates -- Raman microscopy for characterization of particles -- Microscopic methods for particle characterization in protein pharmaceuticals -- Comparison of methods for soluble aggregate detection and size characterization -- Protein purification and its relation to protein aggregation and particles -- Formulation development and its relation to protein aggregation and particles.

Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries

001735651

full

(Au-PeEL)EBL818481

(CaONFJC)MIL340104

(CaPaEBR)ebr10521349

(MiAaPQ)EBC818481

(OCoLC)768082726