.

0 (hodnocen0 x )

EB

ONLINE

Washington, D.C. : National Academies Press, c2008

1 online resource (xii, 124 p.) : ill. (some col.)

ISBN 0309116686

ISBN 9780309116688

Includes bibliographical references

Introduction -- New clinical trial designs. Phase 0 trials -- Adaptive trial designs -- Targeting multiple pathways with multiple drugs -- Preclinical model systems -- Molecular imaging. Current and developing methods -- Challenges of molecular imaging -- Screening for predictive markers. The challenges of clinical validation -- Bioimaging predictive markers -- Clinical translation -- Panel discussion -- Costs of clinical trials. Regulatory costs -- Patient accrual -- Global outsourcing -- Time is money -- Public-private collaborations -- Regulatory issues. Regulatory barriers to innovation -- Patient advocacy perspective -- Regulation of in vitro diagnostics -- Regulatory issues in improving cancer clinical trials -- Reports from the case study discussion groups. Adaptive trial design -- Phase 0 trials -- Imaging -- Use of proteomics/genomics to assign therapy in lung cancer -- Use of genetics/genomics to assign therapy.

Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries

001825464

full

(Au-PeEL)EBL3378368

(CaONFJC)MIL172680

(CaPaEBR)ebr10235163

(MiAaPQ)EBC3378368

(OCoLC)923278949