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0 (hodnocen0 x )

EB

ONLINE

1st ed.

Gottingen : Cuvillier Verlag, 2021

1 online resource (141 pages)

ISBN 9783736964327 (electronic bk.)

ISBN 9783736974326

Wissenschaftliche Reihe der Klinik fur Pferde ; v.51

Print version: Weber, Lisa Annabel In vitro and in vivo development of a topical drug for the treatment of equine skin cancer – based on naturally occurring and synthetically modified substances in plane bark Gottingen : Cuvillier Verlag,c2021 ISBN 9783736974326

Intro -- LIST OF ABBREVIATIONS -- SUMMARY -- ZUSAMMENFASSUNG -- 1. Introduction -- 1.1. The equine malignant melanoma -- 1.2. The equine sarcoid: an overview -- 1.3. Topical drug application -- 1.4. Naturally occurring substances in plane bark and their syntheticallymodified derivatives -- 1.5. Hypotheses and aims of the thesis -- 2. Manuscript I:Betulinic acid shows anticancer activity against equine melanoma cells andpermeates isolated equine skin in vitro -- 2.1. Supplemental data -- 3. Manuscript II:In vitro assessment of triterpenoids NVX-207 and betulinyl-bis-sulfamate asa topical treatment for equine skin cancer -- 4. Manuscript III:Concentration profiles and safety of topically applied betulinic acid andNVX-207 in eight healthy horses - A randomized, blinded, placebocontrolled,crossover pilot study -- 5. Manuscript IV:Effects of topically applied betulinic acid and NVX-207 on early stageequine melanoma - A prospective, randomized, double-blind, placebocontrolledpilot study -- 6. General discussion -- 6.1. Summarized findings -- 6.2. Interpretation of the findings -- 7. Major findings and conclusions -- 8. Future perspectives -- 9. References -- Affidavit -- Acknowledgements.

001904982

express

(Au-PeEL)EBL6636881

(MiAaPQ)EBC6636881

(OCoLC)1256237389