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0 (hodnocen0 x )

EB

EB

ONLINE

London : Academic Press, 2022

1 online resource

ISBN 9780323858762 (electronic bk.)

ISBN 0323858767 (electronic bk.)

ISBN 9780323858731

ISBN 0323858732

Original ISBN 0323858732 ISBN 9780323858731

Front Cover -- Combination Drug Delivery Approach as an Effective Therapy for Various Diseases -- Copyright Page -- Dedication -- Contents -- List of contributors -- Preface -- Acknowledgments -- A. Combination drug delivery approaches against various diseases -- 1 Overcoming cancer drug resistance via nanomedicine-based combined drug delivery -- 1.1 Introduction -- 1.2 Organic nanocarriers -- 1.2.1 Lipid-based systems -- 1.2.1.1 Liposomal formulations -- 1.2.1.2 Solid lipid nanoparticles -- 1.2.1.3 Nanostructured lipid carriers -- 1.2.1.4 Nanoemulsion -- 1.2.2 Protein-based nanocarriers

1.2.3 Polymeric nanoparticles -- 1.3 Inorganic nanocarriers -- 1.3.1 Iron oxide nanoparticles -- 1.3.2 Quantum dots -- 1.3.3 Gold nanoparticles -- 1.3.4 Mesoporous silica nanoparticles -- 1.3.5 Carbon-based nanocarriers -- 1.3.5.1 Graphene -- 1.3.5.2 Carbon nanotubes -- 1.4 Conclusion -- References -- 2 Overcoming the challenges of drug resistance through combination drug delivery approach -- 2.1 Introduction -- 2.2 Drug resistance in cancer -- 2.2.1 Intrinsic and acquired drug resistance -- 2.2.2 Mechanisms of drug resistance -- 2.2.2.1 Elevated drug efflux -- 2.2.2.2 Tumor microenvironment

2.2.4.4.1 Antibodies -- 2.2.4.4.2 Peptides and proteins -- 2.2.5 Conclusion -- 2.3 Combination drug delivery approach to overcome antimicrobial resistance -- 2.4 Conclusion -- References -- 3 Combination drug delivery approaches in ophthalmology -- 3.1 The eye -- 3.2 The need for new ophthalmic treatments -- 3.2.1 Increasing prevalence of ocular diseases -- 3.2.1.1 Age as risk factor -- 3.2.1.2 Susceptibility to exogenous threats -- 3.2.1.3 Refractive surgery for myopia -- 3.2.2 The difficulty of drugs to reach their intraocular target

2.2.2.3 Enhanced DNA repair -- 2.2.2.4 Other mechanisms -- 2.2.3 Combinational drug delivery systems in cancer drug resistance -- 2.2.3.1 Nanoparticulate drug delivery systems -- 2.2.4 Combinational therapies via nanoparticulate systems -- 2.2.4.1 Combination of different chemotherapeutics -- 2.2.4.2 Combination of chemotherapeutics and sensitizing agents -- 2.2.4.2.1 P-gp inhibitors -- 2.2.4.2.2 Autophagy inhibitors -- 2.2.4.3 Combination of chemotherapeutics and genes -- 2.2.4.3.1 Plasmid DNA -- 2.2.4.3.2 RNAs -- 2.2.4.4 Combination of chemotherapeutics and protein-based molecules

3.2.3 Adverse ocular effects of topically administered drugs -- 3.3 Drug-device combinations in ophthalmology -- 3.3.1 Drug-device combinations for glaucoma -- 3.3.2 Drug-device combinations for surgeries -- 3.3.3 Drug-device combinations for ocular infections and inflammations -- 3.3.4 Drug-device combinations for dry eye disease -- 3.4 Challenges and future perspectives -- References -- 4 Combination drug delivery system to enhance the transdermal drug delivery of bioactive molecules -- 4.1 Introduction -- 4.2 Physiological skin row versus percutaneous permeation of bioactive molecules

001932019

(OCoLC)1306276987